Result on the sensitivity test of the pulmonary tuberculosis patients treated with antituberculous drugs

Chang, Kwang Sub; Kim, Ki Ho; Kim, Yong Hyun

doi:1960.0.9.34

Tuberc Respir Dis > Issue 9; 1960 > Article

Tuberculosis and Respiratory Diseases 1960;9:34-37.
DOI: https://doi.org/10.4046/trd.1960.9.1.34 Published online December 1, 1960.

Result on the sensitivity test of the pulmonary tuberculosis patients treated with antituberculous drugs

Kwang Sub Chang¹, Ki Ho Kim¹, Yong Hyun Kim²

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
²National Institude of Immunology, Korea

폐결핵환자의 결핵균검색에 관한 연구: 제1보 중증폐결핵환자의 화학치료와 결핵균의 내성상황

장광섭¹, 김기호¹, 김용현²

Abstract

In the treatment of the tuberculosis, the due consideration must be paid for the good knowledge of resistance of the tuberculous bacilli against the antituberculous agents. In this study, we observed the relationship of the emergence of resistance to the length of medication in each antituberculous agent separately, and also evaluation of the reliability of the results of sensitivity test to clinical manifestation has been checked. 1) For 56 pulmonary tuberculosis patients, mostly far advanced, and with cavitation have been under the combined chemotherapy for considerable duration, the sensitivity of the SM, PAS and INH of each calculated in the length of its medications. This ablation revealed that a) In early stage of medications, tendency of emergence of resistance is definitively less in PAS compared with those in SM and INH. b) But at last, after months medication all of three agents gained resistance in 100% of cases. 2) For the evaluation of reliability test in clinical manifestation, 56 patients divided insensitive and resistant groups, and each group was checked in subjective symptoms and X-Ray findings and tabulated by the scales of improve, no change and deterioration. From this observation, we found that. a) Insensitive group, about 50% improve, 5% deteriorated and 45% no change. b) In resistant group, about 10% improve, 25% deteriorate and 65% no change.

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