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Original Article
COPD
Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea
Hyun Woo Ji, Soojoung Yu, Yun Su Sim, et al.
Tuberc Respir Dis. 2025;88(2):292-302.   Published online December 30, 2024
Background: Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods: This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens,...
Original Article
COPD
Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study
Tai Joon An, Youlim Kim, Hyun Lee, et al.
Tuberc Respir Dis. 2025;88(2):303-309.   Published online February 4, 2025
Background: Computed tomography (CT) scans are utilized to assess emphysema, a prominent phenotype of chronic obstructive pulmonary disease (COPD). Variability in CT protocols and equipment across hospitals can impact accuracy. This study aims to implement kernel conversion across different CT settings and evaluate changes in the correlation between the emphysema index pre- and post-kernel conversion, along with clinical measures in...
Original Article
COPD
Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease
Sang Min Han, Hyo Seon Kim, Seung Yong Park, et al.
Tuberc Respir Dis. 2025;88(2):310-321.   Published online February 6, 2025
Background: This study evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Korean guidelines in the prescription patterns of respiratory specialists for stable chronic obstructive pulmonary disease (COPD) management. Methods: Data were collected on medications from 2011 to 2022 using the Korea COPD Subtype Study (KOCOSS) cohort. Patients were divided into two groups: those registered before and...
Original Article
COPD
Management of Chronic Obstructive Pulmonary Disease in Vietnam during the COVID-19 Period: Current Situation and Challenges
Thuy Thanh Phan, Giap Van Vu, Chau Quy Ngo
Tuberc Respir Dis. 2025;88(2):322-333.   Published online February 7, 2025
Background: To assess the alterations in exacerbation rates, other clinical outcomes, and to identify persistent challenges in the management of chronic obstructive pulmonary disease (COPD) in Vietnamese COPD management units (CMUs). Methods: A multi-center, prospective cohort study was conducted on COPD within the CMUs of three study sites. The primary endpoint was exacerbation frequency. Data on demographic and clinical characteristics were...
Original Article
Lung Cancer
Better Chemotherapeutic Response of Small Cell Lung Cancer in Never Smokers than in Smokers
Ha-Young Park, Hyung-Joo Oh, Hwa Kyung Park, et al.
Tuberc Respir Dis. 2025;88(2):334-341.   Published online February 11, 2025
Background: Small cell lung cancer (SCLC) is called ‘smoker’s disease’ because it is strongly associated with smoking and most cases occur in smokers. However, it can also occur in never smokers. We investigated the clinical features of never smokers with SCLC and compared their treatment outcomes with those of smokers with SCLC. Methods: We retrospectively reviewed the clinical data of patients...
Original Article
Lung Cancer
Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer
Hyo Jin Kim, Ui Ri An, Han Jee Yoon, et al.
Tuberc Respir Dis. 2025;88(2):342-352.   Published online February 13, 2025
Background: Histone deacetylase (HDAC) inhibition offers potential anticancer effects across diverse cancers due to HDAC's significant role in cancer development and progression. Consequently, we demonstrated the therapeutic efficacy of the novel HDAC inhibitor, CG-745, in comparison with existing inhibitors such as suberoylanilide hydroxamic acid (SAHA) in non-small cell lung cancer (NSCLC) cells. Methods: CG-745's effect on apoptosis and reactive oxygen species...
Original Article
Tuberculosis
Bibliometric Analysis of Nontuberculous Mycobacteria Research in South Korea
Geunin Lee, Young Ae Kang, Youngmok Park
Tuberc Respir Dis. 2025;88(2):353-360.   Published online January 14, 2025
Background: Current research on nontuberculous mycobacteria (NTM) is multidisciplinary, necessitating proper organization to obtain comprehensive insight. Therefore, a bibliometric analysis was performed to identify NTM research characteristics in South Korea. Methods: The Web of Science was searched for NTM articles authored by Koreans at Korean institutions until March 2023. We collected data on authors, publication year, article type, study design, research...
Original Article
Critical Care Medicine
Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors
Jong Hwan Jeong, Manbong Heo, Sunghoon Park, et al.
Tuberc Respir Dis. 2025;88(2):361-368.   Published online December 5, 2024
Background: The development of frailty at hospital discharge affects the clinical outcomes in severe coronavirus disease 2019 (COVID-19) survivors who had no frailty before hospitalization. We aimed to describe the prevalence of new frailty using the clinical frailty scale (CFS) and evaluate its associated factors in patients with severe COVID-19 without pre-existing frailty before hospitalization. Methods: We performed a secondary analysis...
Original Article
Critical Care Medicine
Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea
Hye Ju Yeo, Daesup Lee, Mose Chun, et al.
Tuberc Respir Dis. 2025;88(2):369-379.   Published online January 6, 2025
Background: Malnutrition exacerbates the prognosis of numerous diseases; however, its specific impact on severe coronavirus disease 2019 (COVID-19) outcomes remains insufficiently explored. Methods: This multicenter study in Korea evaluated the nutritional status of 1,088 adults with severe COVID-19 using the Geriatric Nutritional Risk Index (GNRI) based on serum albumin levels and body weight. The patients were categorized into two groups: GNRI...
Original Article
Critical Care Medicine
Understanding of Patients with Severe COVID-19 Using Lung Ultrasound
Seo-Hee Yang, Eun Ju Park, Jung-Hyun Kim, et al.
Tuberc Respir Dis. 2025;88(2):380-387.   Published online January 6, 2025
Background: Lung ultrasound (LUS) has proven valuable in the initial assessment of coronavirus disease 2019 (COVID-19), but its role in detecting pulmonary fibrosis following intensive care remains unclear. This study aims to assess the presence of pulmonary sequelae and fibrosis-like changes using LUS in survivors of severe COVID-19 pneumonia one month after discharge. Methods: We prospectively enrolled patients with severe COVID-19...
Original Article
Miscellaneous
Features of Lung Cyst in Birt-Hogg-Dubé Syndrome from Patients with Multiple Lung Cysts
Yong Jun Choi, Hye Jung Park, Chi Young Kim, et al.
Tuberc Respir Dis. 2025;88(2):388-398.   Published online November 25, 2024
Background: High-resolution chest computed tomography (CT) is a crucial assessment tool for diagnosing Birt-Hogg-Dubé (BHD) syndrome. This study aimed to analyze differences of lung cysts between BHD and other cystic lung diseases. Methods: From January 2020 to December 2022, patients with multiple lung cysts who underwent chest CT at Gangnam Severance Hospital were included. Results: Over a 3-year period (from January 2020...
Original Article
Miscellaneous
Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid
Lam Nguyen-Ho, Hoang Kim Tu Trinh, Vu Le-Thuong, et al.
Tuberc Respir Dis. 2025;88(2):399-407.   Published online January 14, 2025
Background: Neutrophil elastase (NE) has been proposed as a potential biomarker for evaluating the severity and prognosis of bronchiectasis. This study aimed to compare bronchial lavage quantification of NE levels and activities with those of sputum. Methods: A cross-sectional study was conducted in which 24 Vietnamese adults with bronchiectasis were enrolled from June 2023 to August 2023. All participants underwent bronchoscopy...
Current Issue
Volume 88(2); Apr 2025
Reviews
Asthma
4923
International Severe Asthma Registry (ISAR): 2017–2024 Status and Progress Update
Désirée Larenas-Linnemann, Chin Kook Rhee, Alan Altraja, John Busby, Trung N. Tran, Eileen Wang, Todor A. Popov, Patrick D. Mitchell, Paul E. Pfeffer, Roy Alton Pleasants, Rohit Katial, Mariko Siyue Koh, Arnaud Bourdin, Florence Schleich, Jorge Máspero, Mark Hew, Matthew J. Peters, David J. Jackson, George C. Christoff, Luis Perez-de-Llano, Ivan Cherrez-Ojeda, João A. Fonseca, Richard W. Costello, Carlos A. Torres-Duque, Piotr Kuna, Andrew N. Menzies-Gow, Neda Stjepanovic, Peter G. Gibson, Paulo Márcio Pitrez, Celine Bergeron, Celeste M. Porsbjerg, Camille Taillé, Christian Taube, Nikolaos G. Papadopoulos, Andriana I. Papaioannou, Sundeep Salvi, Giorgio Walter Canonica, Enrico Heffler, Takashi Iwanaga, Mona S. Al-Ahmad, Sverre Lehmann, Riyad Al-Lehebi, Borja G. Cosio, Diahn-Warng Perng, Bassam Mahboub, Liam G. Heaney, Pujan H. Patel, Njira Lugogo, Michael E. Wechsler, Lakmini Bulathsinhala, Victoria Carter, Kirsty Fletton, David L. Neil, Ghislaine Scelo, David B. Price
Tuberc Respir Dis. 2025;88(2):193-215.   Published online February 6, 2025
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COPD
4920
Pharmacologic Therapies for Preventing Chronic Obstructive Pulmonary Disease Exacerbations: A Comprehensive Review
Hyun Woo Lee
Tuberc Respir Dis. 2025;88(2):216-227.   Published online February 4, 2025
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Lung Cancer
Update in Association between Lung Cancer and Air Pollution
Jiye Yoo, Yongchan Lee, Youngil Park, Jongin Lee, Joon Young Choi, Heekwan Lee, Jeong Uk Lim
Tuberc Respir Dis. 2025;88(2):228-236.   Published online December 11, 2024
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Interstitial Lung Disease
4913
Korean Guidelines for Diagnosis and Management of Idiopathic Nonspecific Interstitial Pneumonia
Yong Suk Jo, Hyun-Kyung Lee, Sun Hyo Park, Joon Sung Joh, Hye Jin Jang, Jong Sun Park
Tuberc Respir Dis. 2025;88(2):237-246.   Published online January 6, 2025
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4916
Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Connective Tissue Disease Associated Interstitial Lung Disease
Ju Hyun Oh, Jae Ha Lee, Sung Jun Chung, Young Seok Lee, Tae-Hyeong Kim, Tae-Jung Kim, Joo Hun Park
Tuberc Respir Dis. 2025;88(2):247-263.   Published online January 10, 2025
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Critical Care Medicine
4927
Home High-Flow Nasal Cannula in Patients with Chronic Respiratory Failure: A Literature Review and Suggestions for Clinical Practice
Youjin Chang, Moon Seong Baek, Sei Won Kim, Su Hwan Lee, Jung Soo Kim, So Young Park, Jin Woo Kim, Jae Hwa Cho, Sunghoon Park
Tuberc Respir Dis. 2025;88(2):264-277.   Published online February 18, 2025
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Miscellaneous
4911
Application of Artificial Intelligence in Thoracic Radiology: A Narrative Review
Woo Hyeon Lim, Hyungjin Kim
Tuberc Respir Dis. 2025;88(2):278-291.   Published online December 17, 2024
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Original Articles
COPD
4912
Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea
Hyun Woo Ji, Soojoung Yu, Yun Su Sim, Hyewon Seo, Jeong-Woong Park, Kyung Hoon Min, Deog Kyeom Kim, Hyun Woo Lee, Chin Kook Rhee, Yong Bum Park, Kyeong-Cheol Shin, Kwang Ha Yoo, Ji Ye Jung
Tuberc Respir Dis. 2025;88(2):292-302.   Published online December 30, 2024
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4919
Kernel Conversion Improves the Correlation between the Extent of Emphysema and Clinical Parameters in Chronic Obstructive Pulmonary Disease: A Multicenter Cohort Study
Tai Joon An, Youlim Kim, Hyun Lee, Hyeon-Kyoung Koo, Naoya Tanabe, Kum Ju Chae, Kwang Ha Yoo
Tuberc Respir Dis. 2025;88(2):303-309.   Published online February 4, 2025
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4922
Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease
Sang Min Han, Hyo Seon Kim, Seung Yong Park, Heung Bum Lee, Young Bum Park, Chin Kook Rhee, Youlim Kim, Seoung Ju Park
Tuberc Respir Dis. 2025;88(2):310-321.   Published online February 6, 2025
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4924
Management of Chronic Obstructive Pulmonary Disease in Vietnam during the COVID-19 Period: Current Situation and Challenges
Thuy Thanh Phan, Giap Van Vu, Chau Quy Ngo
Tuberc Respir Dis. 2025;88(2):322-333.   Published online February 7, 2025
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Lung Cancer
4925
Better Chemotherapeutic Response of Small Cell Lung Cancer in Never Smokers than in Smokers
Ha-Young Park, Hyung-Joo Oh, Hwa Kyung Park, Joon-Young Yoon, Chang-Seok Yoon, Bo Gun Kho, Tae-Ok Kim, Hong-Joon Shin, Chul-Kyu Park, Yong-Soo Kwon, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, In-Jae Oh
Tuberc Respir Dis. 2025;88(2):334-341.   Published online February 11, 2025
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4926
Comparison of Anticancer Effects of Histone Deacetylase Inhibitors CG-745 and Suberoylanilide Hydroxamic Acid in Non-small Cell Lung Cancer
Hyo Jin Kim, Ui Ri An, Han Jee Yoon, Hyun Lim, Ki Eun Hwang, Young Suk Kim, Hak Ryul Kim
Tuberc Respir Dis. 2025;88(2):342-352.   Published online February 13, 2025
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Tuberculosis
4918
Bibliometric Analysis of Nontuberculous Mycobacteria Research in South Korea
Geunin Lee, Young Ae Kang, Youngmok Park
Tuberc Respir Dis. 2025;88(2):353-360.   Published online January 14, 2025
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Critical Care Medicine
4909
Prevalence of New Frailty at Hospital Discharge in Severe COVID-19 Survivors and Its Associated Factors
Jong Hwan Jeong, Manbong Heo, Sunghoon Park, Su Hwan Lee, Onyu Park, Taehwa Kim, Hye Ju Yeo, Jin Ho Jang, Woo Hyun Cho, Jung-Wan Yoo
Tuberc Respir Dis. 2025;88(2):361-368.   Published online December 5, 2024
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4915
Relationship between the Geriatric Nutrition Risk Index and the Prognosis of Severe Coronavirus Disease 2019 in Korea
Hye Ju Yeo, Daesup Lee, Mose Chun, Jin Ho Jang, Sunghoon Park, Su Hwan Lee, Onyu Park, Tae Hwa Kim, Woo Hyun Cho
Tuberc Respir Dis. 2025;88(2):369-379.   Published online January 6, 2025
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4914
Understanding of Patients with Severe COVID-19 Using Lung Ultrasound
Seo-Hee Yang, Eun Ju Park, Jung-Hyun Kim, Jin Woo Song, Young-Jae Cho
Tuberc Respir Dis. 2025;88(2):380-387.   Published online January 6, 2025
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Miscellaneous
4907
Features of Lung Cyst in Birt-Hogg-Dubé Syndrome from Patients with Multiple Lung Cysts
Yong Jun Choi, Hye Jung Park, Chi Young Kim, Bo Mi Jung, Jae Hwa Cho, Min Kwang Byun
Tuberc Respir Dis. 2025;88(2):388-398.   Published online November 25, 2024
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4917
Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid
Lam Nguyen-Ho, Hoang Kim Tu Trinh, Vu Le-Thuong, Kieu Minh Le, Van Thanh Niem Vo, Diem My Vu, Ngoc Tran-Van, James D. Chalmers
Tuberc Respir Dis. 2025;88(2):399-407.   Published online January 14, 2025
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Letters to the Editor
COPD
Request for Study Design Modification in Examining Nutritional Intake and Muscle Strength in Individuals with Airflow Limitation
Ming-Che Chang, Chii-Lan Lin, Fong-Fong Tsai, Hwei-Mei Tai, Chih-Wei Kuo, Hon-Kwong Ma, Chih-Chung Shiao
Tuberc Respir Dis. 2025;88(2):408-410.   Published online November 25, 2024
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4921
Authors´ Response: Additional Analyses of Nutritional Intake and Muscle Strength in Individuals with Airflow Limitation
I Re Heo, Ho Cheol Kim
Tuberc Respir Dis. 2025;88(2):411-412.   Published online February 6, 2025
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Tuberculosis and
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Online ISSN: 2005-6184

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