| Studies on Resistance of acid Fast Bacilli to Anti-Tuberculous Agents 2) Difference in sensitivity between S and R forms of soil acid fast bacilli to chemotherapeutic agents |
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Jae Kyu Chung |
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Department of Bacteriology School of Medicine, Kyungpook National University, Korea |
| 항산균의 항결핵제내성에 관한 연구 (제2보) -토양항산균의 S-R 변이와 약제감수성관계- |
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정재규 |
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| Abstract |
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In the previous communication, difference is sensitivity to chemotherapeutic agents were detected between the S and R forms. In the present report, this relationship is discussed in detail, the R variants were induced with S strain by blind transfer in Long's media Also the S, R. colonies were segregated directly by single step in Long’s media.
These R forms and R colonies were significantly more sensitve to chemotherapeutic agents and slower in growth rate as compare to the original S forms. The significance of nutritional elements in the sensitivity test was discussed and marked differences were noticed in the same strain depending upon the difference in the culture medium. |
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