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Tuberc Respir Dis > Volume 40(5); 1993 > Article
Case Report
Tuberculosis and Respiratory Diseases 1993;40(5):610-615.
DOI: https://doi.org/10.4046/trd.1993.40.5.610    Published online October 1, 1993.
Two cases of silicone- induced pulmonary embolism.
Bock Hyun Jung, Young Ill Suh, Jae Myoung Lee, Sook Hee Song, Ho Joong Kim, Myoung Koo Lee, In Gyu Hyun, Ki Suck Jung, Hyung Sick Shin
1Department of Internal Medicine, Hallym University School of Medicine, Seoul, Korea
2Department of Pathology, Hallym University School of Medicine, Seoul, Korea
Abstract
Silicone (polydimethylsiloxane) has widely been used in breast augmentation and other cosmetic procedures. Despite the stability of its chemical nature, local and systemic adverse reactions associated with silicone have been reported. There were several patients who suffered from pulmonary embolism associated with injection of silicone. Silicone-induced pneumonitis and sudden death after subcutaneous injection of silicone has been also described. However, there is no case in the literature of clinically diagnosed silicone-induced pulmonary embolism in Korea. We experienced 2 women who developed respiratory symptoms after illicit subcutaneous injection of silicone for the purpose of colporrhaphy. One patient was admitted because of dyspnea, chest pain, hemoptysis and bilateral pulmonary infiltration after repeated injection of silicone. Pulmonary function test initially showed severe restrictive pattern and transbronchial lung biopsy disclosed numerous oil-like material filling the alveolar septal capillaries and macrophages. High resolution C. T., bronchoalveolar lavage, transbronchial lung biopsy and pulmonary angiogram disclosed abnormalities compatible with silicone fluid-induced pulmonary embolism. The other patient expired shortly after arrival in the emergency room. It is suggested that illicit injection of silicone fluid carries serious respiratory problems and can induce pulmonary embolism followed by acute respiratory failure.
Key Words: Silicone, Pulmonary embolism, Pneumonitis
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