Change of IFN-g and TNF-a Producing Capacity in the Course of Chemotherapy in Patients with Pulmonary Tuberculosis.

Yim, Jae Joon; Lee, Sang Min; Lee, Jae Ho; Yoo, Chul Gyu; Lee, Choon Taek; Chung, Hee Soon; Kim, Young Whan; Han, Sung Koo; Shim, Young Soo

doi:2000.48.2.149

Tuberc Respir Dis > Volume 48(2); 2000 > Article

Original Article

Tuberculosis and Respiratory Diseases 2000;48(2):149-154.
DOI: https://doi.org/10.4046/trd.2000.48.2.149 Published online February 1, 2000.

Change of IFN-g and TNF-a Producing Capacity in the Course of Chemotherapy in Patients with Pulmonary Tuberculosis.

Jae Joon Yim, Sang Min Lee, Jae Ho Lee, Chul Gyu Yoo, Choon Taek Lee, Hee Soon Chung, Young Whan Kim, Sung Koo Han, Young Soo Shim

Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND
Interferon-gamma (IFN-g) and tumor necrosis factor-alpha (TNF-a) play a critical role in protective immunity against Mycobacterium tuberculosis infection. (The change )of IFN-g and TNF-a producing capacity in the course of antituberculous chemotherapy in patients with pulmonary tuberculosis (was evaluated in this study.) METHOD: In 29 patients with pulmonary tuberculosis, phytohemagglutinin(PHA) or purified protein derivative(PPD) stimulated production of IFN-g and TNF-a by peripheral blood mononuclear cells was quantified. Five patients were sampled before they underwent antituberculous treatment, 11 patients after 0 -4 months, six after 4 -completion and seven after treatment completion. RESULT: There was no difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between each group. CONCLUSION: No difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between two groups could be identified during classification of patients with pulmonary tuberculosis by their treatment stages.

Key Words: tuberculosis, interferon-gamma, tumor necrosis factor-alpha