Two Cases of Microscopic Polyangiitis.

Song, Kyoung Eun; Im, Seung Guan; Jo, Sook Kyoung; Jung, Youn Mu; Choi, Joon Hyuck; Sheen, Seung Soo; Oh, Yoon Jung; Park, Kwang Joo; Hwang, Sung Chul; Yim, Hyun Ee

doi:2003.55.6.623

Tuberc Respir Dis > Volume 55(6); 2003 > Article

Case Report

Tuberculosis and Respiratory Diseases 2003;55(6):623-630.
DOI: https://doi.org/10.4046/trd.2003.55.6.623 Published online December 1, 2003.

Two Cases of Microscopic Polyangiitis.

Kyoung Eun Song, Seung Guan Im, Sook Kyoung Jo, Youn Mu Jung, Joon Hyuck Choi, Seung Soo Sheen, Yoon Jung Oh, Kwang Joo Park, Sung Chul Hwang, Hyun Ee Yim

¹Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea. schwang@ajou.ac.kr
²Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

Abstract

Microscopic polyangiitis is a systemic small-vessel vasculitis that is primarily associated with necrotizing glomerulonephritis and pulmonary capillaritis. Lung involvement is characterized by a diffuse alveolar hemorrhage. However, rarely central nervous system involvement has been reported to be occurred with the microscopic polyangiitis. Relapse of microscopic polyangiitis are reported to be more frequent than those of polyarteritis nodosa, often after a reduction or discontinuation of the therapy. We would like to report two patients with microscopic polyangiitis. One presented with clinical manifestations of both lung and central nervous system involvements and the other was a case of recurrence during steroid tapering following the steroid pulse therapy.

Key Words: Microscopic polyangiitis, ANCA, CNS vasculitis, Diffuse alveolar hemorrhage syndrome