| Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report. |
|
Ji Hye Oh, Kyung Chan Kim, Sung Woo Kim, Dae Sung Hyun, Sang Chae Lee, Sung Hwa Bae, Kyung Jae Jung, Kun Young Kwon |
1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.
2Department of Radiology, Catholic University of Daegu School of Medicine, Daegu, Korea.
3Department of Pathology, Keimyung University School of Medicine, Daegu, Korea. solarmac@cu.ac.kr |
|
|
| Abstract |
|
Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient's pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT. |
| Key Words:
Bone marrow transplantation, Bronchiolitis obliterans, Pulmonary function, Azithromycin |
|
PDF Links
Full text via DOI
Download Citation
