The Clinical and Pathologic Features according to Expression of Acyl Protein Thioesterase-1 (APT1) in Stage I Non-small Cell Lung Cancer.

Shin, Jung Ar; Lee, Chang Ryul; Byun, Min Kwang; Chang, Yoon Soo; Kim, Se Kyu; Chang, Joon; Ahn, Chul Min; Kim, Hyung Jung

doi:2010.68.4.212

Tuberc Respir Dis > Volume 68(4); 2010 > Article

Original Article

Tuberculosis and Respiratory Diseases 2010;68(4):212-217.
DOI: https://doi.org/10.4046/trd.2010.68.4.212 Published online April 1, 2010.

The Clinical and Pathologic Features according to Expression of Acyl Protein Thioesterase-1 (APT1) in Stage I Non-small Cell Lung Cancer.

Jung Ar Shin, Chang Ryul Lee, Min Kwang Byun, Yoon Soo Chang, Se Kyu Kim, Joon Chang, Chul Min Ahn, Hyung Jung Kim

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. khj57@yuhs.ac
²Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.

Abstract

BACKGROUND
Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. METHODS: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. RESULTS: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. CONCLUSION: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.

Key Words: Acyl protein thioesterase, Carcinoma, Non-Small-Cell Lung, Biological Markers

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