Tuberc Respir Dis > Volume 71(5); 2011 > Article
Tuberculosis and Respiratory Diseases 2011;71(5):368-372.
DOI: https://doi.org/10.4046/trd.2011.71.5.368    Published online November 1, 2011.
Severe Acute Fibrinous and Organizing Pneumonia with Acute Respiratory Distress Syndrome.
Hyo Jae Kang, Sun Mi Choi, Yun Jeong Jeong, Jong Sun Park, Sei Won Lee, Ho Il Yoon, Jae Ho Lee, Choon Tack Lee, Young Jae Cho
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.
2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. lungdrcho@gmail.com
Abstract
Acute fibrinous and organizing pneumonia is a newly recognized pattern of acute lung injury. A 49-year-old female presented with a cough and worsening dyspnea on exertion. She had no history of smoking and no specific past medical history except exposure of home humidifier containing sterilizer. A chest computed tomography scan showed patchy consolidation with fibrosis in the right lower lobe and ill-defined centrilobular ground glass opacity in both lungs. The pathological findings were patchy areas of lung parenchyma with fibrin deposits in the alveolar ducts and alveoli, and fibrin balls with hemosiderin deposition in the alveolar spaces. The histological pattern of our case is differentiated from diffuse alveolar damage by the absence of hyaline membranes, and from eosinophilic pneumonia by the lack of eosinophils. In our case, the patient was treated with corticosteroid pulse therapy. However, the clinical course became aggravated and she died within two weeks.
Key Words: Acute Respiratory Distress Syndrome, Organizing Pneumonia, Cryptogenic, Inhalation Exposure


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