| Epidemiological Characteristics of Nontuberculous Mycobacterial Pulmonary Disease in South Korea: A Meta-Analysis of Individual Participant Data |
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Geunin Lee1, Sol Kim1, Shihwan Chang1, Hojoon Sohn2, Young Ae Kang1,3, Youngmok Park1,4 |
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
2Department of Preventive Medicine, Seoul National University, Seoul, Republic of Korea
3Institute of Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea
4Institute for Innovation in Digital Healthcare, Yonsei University, Seoul, Republic of Korea |
Correspondence:
Youngmok Park, Tel: +82-2-2228-1952, Fax: +82-2-393-6884,
Email: 0mokfv@yuhs.ac
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Received: 13 December 2023 • Revised: 29 February 2024 • Accepted: 7 April 2024
*Geunin Lee and Sol Kim contributed equally to this study as co-first authors. |
| Abstract |
Rationale
Despite the global increase in nontuberculous mycobacterial pulmonary disease (NTM-PD), there are geographical variations in clinical characteristics. We investigated the clinical characteristics of patients with NTM-PD in South Korea.
Methods
We systematically reviewed articles about patients with NTM-PD in South Korea until February 2022. Individual participant data, regardless of treatment, were collected using a standard case report form.
Results
The data of 6,489 patients from 11 hospitals between 2002 and 2019 were analyzed. The mean age was 61.5 ± 11.7 years, and 57.7% were women. Mycobacterium avium (41.4%) and Mycobacterium intracellulare (38.4%) comprised most of the causative species, followed by Mycobacterium abscessus subspecies abscessus (8.6%) and Mycobacterium abscessus subspecies massiliense (7.8%). Bronchiectasis (59.4%) was the most common pulmonary comorbidity. Reported cases of NTM-PD increased over the years, but the proportions of causative species and radiologic forms remained similar. Distinct clinical characteristics were observed according to age and sex. Men were older at the time of diagnosis (median 63.8 vs. 59.9 years, P<0.001) and had more cavitary lesions than women (38.8% vs. 21.0%, P<0.001). The older group (≥65 years) had a higher proportion of patients with body mass index <18.5 kg/m2 (27.4% vs. 18.6%, P<0.001) and cavitary lesions (29.9% vs. 27.6%, P=0.009) than the younger group.
Conclusion
We performed a meta-analysis of the clinical characteristics of patients with NTM-PD in South Korea. We found age- and sex-related differences in disease-specific severity. Further investigation would enhance our comprehension of the disease’s nature and inherited and acquired host factors. |
| Key Words:
age, epidemiology, nontuberculous mycobacteria, sex |
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