| PREVALENCE OF PRIMARY DRUG RESlSTANCE IN KOREA DURING 1963-1964 |
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Sung Chin Kim |
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Central Tuberculosis Laboratory, Korean National Tuberculosis Association |
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| Abstract |
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During 1962-1963, 233 previously untreated tuberculosis patients were examined for prevalence of primary drug resistance to INH,PAS,SM The specimens were collected from 9 Health Centers, 6 General Hospitals and Tuberculosis clinics in Seoul City. specimens were cultured quantitatively and method of indirect sensitivity test to all strains was employed. Bacterial populations from each drug concentration were observed. 1% KH2PO4 Ogawa medium was used. Drug concentrations are follows:(concentrated before inspissation) INH 0.2, 1, 5, (mcg per ml) PAS 1,5. SM 10,20 Criteria of drug resistance. INH: more than 5 colonies on 0.2 mcg, per ml. PAS: More than 5 colonies on 1 mcg per ml. SM: Morea than 5 coloniesces: on 5 mcg per ml. Complete resistance: more than 75% of colonies growth on drug containing medium. Partial resistance: less than 74% of colony growth on drug containing medium. Summarized results: 1. Average rate of primary resistance was 17.8%; 14.7% in 1962 and 23.4% in 1963. 2. In 1962, 7.7% to INH, 3.8% to PAS and 8.3% to SM were resistant In9163, 14.3% to INH, 9.1% to PAS and 7.8% to SM were resistant. 3. Bacterial population among these resistant strains were observed; Complete or partial resistance on the lowest INH concentration (0.2mcg ml) was shown as mesame, but higher than that (1 mg and 5 mcg/ml) were very few. A few Completely resistant strains to PAS, SM, were observed. Most were shown as partial resistance strains. The rate was lower as the concentration of drugs was higher. |
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