| Association between Respiratory Symptoms and Specific IgE, IgG, and IgG4 Antibodies to Reactive Dye (Black GR) in Dye-Exposed Workers |
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Jung Eun Suh1, Jai Nam Park1, Young Soo Cho1, Yeon Sik Lim1, Dong Wook Choi1, Jin Heum Baik1, Hae Sim Park1, Nam Soo Rhu1, Dong Ill Cho1, Jae Won Kim1, Chein Soo Hong2 |
1Department of Chest Medicine, National Medical Center, Seoul, Korea
2Department of Internal Medicine, Yonsei University, College of Medicine, , Seoul, Korea |
| 반응성 염료에 노출된 직업성 천식 환자에서 호흡기 증세와 염료-특이 IgE, IgG 및 IgG4 항체에 관한 연구 |
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서정은1, 박재남1, 조영수1, 임연식1, 최동욱1, 백진흠1, 박해심1, 유남수1, 조동일1, 김재원1, 홍천수2 |
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| Abstract |
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Previous studies revealed that Black GR is known to be the most frequent sensitizer among reactive dyes. Positive skin test and the presence of serum specific IgE antibodies to reactive dyes in exposed workers suggested that their respiratory symptoms provoked by reactive dyes could be an IgE. mediated reaction.
To evaluate the significance of specific IgE and IgG antibodies in the development of respiratory symptoms, we studied the prevalence of specific IgE antibody to Black GR.human serum albumin (HSA) conjugate by RAST and specific IgG and IgG4 antibody to Black GR.HSA conjugate by enzyme linked immunosorbent assay in 309 workers employed in a dye industry. We also performed methacholine bronchial challenge test and dye-bronchoprovocation test in 78 symptomatic workers identified by the questionnaire. When the subjects were classified into three groups as follows: Group 1 includes asymptomatic sensitizers, Group II includes workers whose methacholine PC 20 ranged from 5.0 to 25 mg/ ml and had serum specific IgE antibodies, and Group III includes workers who showed positive responses on Black GR-bronchoprovocation test and had serum specific antibodies, significant differences were found in skin reactivity to Black GR and Black GR-specific IgE level between Group 1 and II (p<0 .05), but no difference was found between Group II and IIl. There was no significant difference in total IgE level among the three groups. There was a significant difference in Black GR-specific IgG level between Group 1 and III (p < 0.05). N0 difference was found in atopy, smoking status and duration of exposure to dyes.
It was suggested that reactive dye-specific IgE mediated reaction might be contributable to the development of bronchial hyperresponsiveness to methacholine in reactive dye-exposed workers and specific IgG level might be associated with the results of dye-bronchoprovocation test. |
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