Fibrinolytic Activity in Patients with Deep Vein Thrombosis

Song, Kyoung Il; Gwok, Jun Goo; Lee, Kwang Hee; Cho, Sung Woo; Jung, Yeon Tae; Kim, Young Hun; Hong, Se Yong; Park, Choon Sik

doi:1989.36.2.142

Tuberc Respir Dis > Volume 36(2); 1989 > Article

Original Article

Tuberculosis and Respiratory Diseases 1989;36(2):142-148.
DOI: https://doi.org/10.4046/trd.1989.36.2.142 Published online June 1, 1989.

Fibrinolytic Activity in Patients with Deep Vein Thrombosis

Kyoung Il Song, Jun Goo Gwok, Kwang Hee Lee, Sung Woo Cho, Yeon Tae Jung, Young Hun Kim, Se Yong Hong, Choon Sik Park

Department of Internal Medicine, Soon Chun Hyang University, Seoul, Korea

정맥혈전증의 발생과 섬유소 용해능과의 관계

송경일, 곽준구, 이광희, 조성우, 정연태, 김용훈, 홍세용, 박춘식

Abstract

In order to evaluate the role of fibrinolytic activity in the generation of deep vèin thrombosis, we measured platelet count, bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time and fibrinogen concentration as coagulation profiles in 2 patients with deep vein thrombosis and 10 patients with combined pulmonary embolism and euglobulin lysis activity as fibrinolytic profile using fibrin plate methods in 6 patients with angiographically proven deep vein thrombosis before and after stimulation with venous occlusion by application with 60 mmHg for 5minutes The results s are as follows 1. Coagulation profiles were in normal ranges except one case in platelet number, one case in prothrombin time and three cases in fibrinogen concentration. 2. Euglobulin lysis time activity were lower in upper and lower extremities of the patient group compared to that of normal control group. 3. Accentuation of euglobulin lysis activity after stimulation was still lower in both extremities of the patients group compared to normal control. 4. Degree of accentuation of euglobulin lysis activity by stimulation was smaller in lower extremities compared to upper extremities in patients with deep vein thrombosis We conclude that the disturbance of fibrinolytic activity, especially in injured vessels, might be a factor to generate deep vein thrombosis with resulting pulmonary embolism.

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