Diagnostic Values of Carcinoembryonic Antigen in Bronchial Washing Fluid

Lee, Joon Seong; Ahn, Sang Yong; Na, Uh Kyun; Lee, Seung Won; Chung, Yeon Tae; Park, Chun Sik

doi:1987.34.3.209

Tuberc Respir Dis > Volume 34(3); 1987 > Article

Original Article

Tuberculosis and Respiratory Diseases 1987;34(3):209-216.
DOI: https://doi.org/10.4046/trd.1987.34.3.209 Published online September 1, 1987.

Diagnostic Values of Carcinoembryonic Antigen in Bronchial Washing Fluid

Joon Seong Lee, Sang Yong Ahn, Uh Kyun Na, Seung Won Lee, Yeon Tae Chung, Chun Sik Park

Department of Internal Medicine, Soonchunhyang University, Hospital

기관지세척액 태아성암항원(Carcinoembryonic Antigen)의 진단적 가치에 대한 연구

이준성, 안상용, 나우균, 이승원, 정연태, 박춘식

Abstract

Synthesis of carcinoembryonic antigen (CEA) is dependent on the epithelial cell function, which could be influenced by malignant change. To evaluate the diagnostic values of CEA in bronchial tree to differente malignant from benign lung disease, CEA was measured in bronchial washing fluid of 42 patients with lung cancer and benign lung diseases. We calculated corrected CEA of bronchial washing fluid which was the ratio of CEA to total protein of bronchial washing fluid to compensate di1ution factor of washing saline. There was no difference of serum CEA concentration between lung cancer and benign lung diseases, but differences of CEA and corrected CEA concentration of bronchial washing fluid between lung cancer and benign lung diseases were significant (p < 0.05) There was no difference of CEA concentration of bronchial washing fluid between smokers and nonsmokers, but differences of serum CEA (p<0.05) and corrected CEA (p < 0.01) of bronchial washing fluid between smokers and nonsmokers were significant. In conclusion, CEA and corrected CEA concentration of bronchial washing fluid in lung cancer are signficantly different from those of benign lung diseases, but may be influenced by other factors. especially smoking. Therefore, CEA measurement of bronchial washing fluid have individually little diagnostic values to differenciate malignancy. But we think it is valuable test when combined with other studies and clinical features.

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