Effect of Multiple Dose Oral Activated Charcoal on Theophylline Pharmacokinetics

Sonds, C.D.; Clemmons, R.L.; Jones, D.W.; Chong, K.S.; Hwong, S.c.; Lee, D.Y.; Loisure, S.c.; Robinson, J. D.

doi:1987.34.2.162

Tuberc Respir Dis > Volume 34(2); 1987 > Article

Original Article

Tuberculosis and Respiratory Diseases 1987;34(2):162-167.
DOI: https://doi.org/10.4046/trd.1987.34.2.162 Published online June 1, 1987.

Effect of Multiple Dose Oral Activated Charcoal on Theophylline Pharmacokinetics

C.D. Sonds¹, R.L. Clemmons¹, D.W. Jones¹, K.S. Chong¹, S.c. Hwong², D.Y. Lee², S.c. Loisure³, J. D. Robinson³

¹Clinical Research Center, Baptist Hospital, Pusan Korea
²Depatment of Internal Medicine, Baptist Hospital, Pusan Korea
³Center for Computer Application in Pharmacy, College of Pharmacy, University of Florida Medical Center, Gainesville, Florida, U.S.A.

경구용 활성탄의 사용이 Theophylline의 약리역동학에 미치는 영향

장관식¹, 황순철¹, 이동윤¹, ³

Abstract

The effect of multiple dose oral activated charcoal on theophylline pharmacokinetics was studied in five healthy, non-smoking, Caucasian adults in a randomized crossover clinical trial. Following an intravenous infusion of aminophylline (6 mg/kg) subjects received either (1) activated charcoal 140 gm in divided doses over 12 hours (treatment group) or (2) water (control group). Serum theophylline concentrations were measured from 0 to 24 hours after the aminophylline infusion Pharmacokinetic parmeters were derived by fitting data points a two compaπment model using a non-linear least squares regression computer program. Treatment with activated charcoal decreased serum theophylline t l /2 from 10.3 to 5.1 hours and the serum AUC from 192.9 to 94.5 mcg/ml.hr, and increased total body clearance of thephylline from 0.590 to 1.099 ml/min/kg These results confirm previous reports that multiple dose activated charcoal increased the total body clearance of theophylline in heallthy subjects, and suggests that this treatment may prove to be efficacious in the treatment of theophylline poisoning, especially in areas where hemoperfusion is not avaiable.