Natural Killer Cell Mediated Cytotoxicity and Antibody-Dependent Cell Mediated Cytotoxicity in Tuberculosis Patients (1)

Kim, Sung Kyu; Oh, Kwang Je; Ahn, Chui Min; Yoon, Yoe Wun; Sohn, Hee Young; Kim, Ki Ho; Choi, In Hong; Yoon, Jung Koo

doi:1986.33.4.196

Tuberc Respir Dis > Volume 33(4); 1986 > Article

Original Article

Tuberculosis and Respiratory Diseases 1986;33(4):196-201.
DOI: https://doi.org/10.4046/trd.1986.33.4.196 Published online December 1, 1986.

Natural Killer Cell Mediated Cytotoxicity and Antibody-Dependent Cell Mediated Cytotoxicity in Tuberculosis Patients (1)

Sung Kyu Kim¹, Kwang Je Oh¹, Chui Min Ahn¹, Yoe Wun Yoon¹, Hee Young Sohn¹, Ki Ho Kim¹, In Hong Choi², Jung Koo Yoon²

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
²Department of Microbioloby, Yonsei University College of Medicine, Seoul, Korea

결핵환자의 자연살해세포 매개 세포파괴능과 항체의존성 세포파괴능에 관한 연구(1)

김성규¹, 오광제¹, 안철민¹, 윤여운¹, 손희영¹, 김기호¹, 최인홍², 윤정구²

Abstract

Cellular immunity is predominantly involved in pulmonary tuberculosis. Natural Killer (NK) cells and Killer (K) cells play an important role in cellular immunity. Natural Killer cell mediated cytotoxicity (NKMC) was studied in 51 patients with active tuberculosis and 39 healthy controls. Antibody-dependent cell mediated cytotoxicity(ADCC) was studied in 41 patients with active tuberculosis and 15 healthy controls There were no differences between the patients and the controls in NKMC and ADCC. There were no significant differences in the mean values of NKMC and ADCC among the minimal, moderately advanced and far advanced pulmonary tuberculosis patients. We conclude that NK and K cells are not of prime importance in the body’s defence against tuberculosis