Peripheral T Cell Subpopulation in Patients with Pulmonary Tuberculosis

Lee, Mi Wan; Chae, Jeong Ha; Moon, Hwa Sik; Song, Jung Sup; Ro, Jae Cheol; Park, Sung Hak; Byun, Hae Won; Kim, Sang Ho

doi:1984.31.4.171

Tuberc Respir Dis > Volume 31(4); 1984 > Article

Original Article

Tuberculosis and Respiratory Diseases 1984;31(4):171-175.
DOI: https://doi.org/10.4046/trd.1984.31.4.171 Published online December 1, 1984.

Peripheral T Cell Subpopulation in Patients with Pulmonary Tuberculosis

Mi Wan Lee¹, Jeong Ha Chae¹, Hwa Sik Moon¹, Jung Sup Song¹, Jae Cheol Ro¹, Sung Hak Park¹, Hae Won Byun¹, Sang Ho Kim²

¹Department of Internal Medicine, Catholic Medical College, Seoul, Korea
²Department of Pathology, Catholic Medical College, Seoul, Korea

결핵 환자의 말초혈액내 T세포아형

이미완¹, 채정하¹, 문화식¹, 송정섭¹, 노재철¹, 박성학¹, 변해원¹, 김상호²

Abstract

To evaluate cellular immunity in patients with pulmonary tuberculosis, peripheral T cell subsets were counted. Pan T cell and T cell subpopulation were observed by using monoclonal antibodies(Leu 1, Leu 2, Leu 3). The results were as follows: 1) Pan T cell, helper T cell and Leu 3/Leu 2 were significantly decreased in patients with pulmonary tuberculosis compared with the normal control group. 2) Suppressor T cell were increased significantly in pulmonary tuberculosis than normal control. 3) There was no significant changes of pan T cell and T cell subpopulation among the patients of the minimal, moderately and far advanced pulmonary tuberculosis. It is suggested that measurement of T cell subpopulation might be explained as one of pathogenesis in pulmonary tuberculosis.