Comparison of Retreatment Regimens for Pulmonary Tuberculosis under Programme Condition

Hong, Young Pyo; Chang, Sung Chil; Kim, Sung Chin

doi:1981.28.3.95

Tuberc Respir Dis > Volume 28(3); 1981 > Article

Original Article

Tuberculosis and Respiratory Diseases 1981;28(3):95-109.
DOI: https://doi.org/10.4046/trd.1981.28.3.95 Published online September 1, 1981.

Comparison of Retreatment Regimens for Pulmonary Tuberculosis under Programme Condition

Young Pyo Hong, Sung Chil Chang, Sung Chin Kim

The Korean Institute of Tuberculosis, Korean National Tuberculosis Association, Seoul, Korea

보건소에 있어서의 폐결핵 시범 재 치료 성적

홍영표, 장승칠, 김성진

Abstract

Under the programme condition, 3 regimens of ethambutol plus morphazinamide plus kanamycin and ethambutol plus morphazinmide plus rifampicin are being compared in the management of patients at Health Centres with pulmonary tuberculosis whose first-line chemotherapy has failed. A total of 1. 017 patients with sputum positive pulmonary tuberculosis, who had previously been treated with first-line drugs for more than one year but not with the drugs under study, were alIocated at random to: EMK (1) ethambutol (24 months) plus morphazinamide (24 months) plus kanamycin (6 months) daily; EMK(2) ethambutol (24 months) plus morphazinamide (12 months) plus kanamycin (6 months) daily; EMK(3) ethambutol (12 months) plus morphazinamide (24 months) plus kanamycin(6 months) daily; and EMR ethambutol (12 months) plus morphazinamide (12 months) plus rifampicin (12 months) daily There were 869 patients (214 EMK(I), 226 EMK(2), 215 EMK(3), 214 EMR) in the main comparison. Of 869 patients admitted to the study, 751 (86%) completed 1 year’s treatment, 118 (14%) patients terminated their treatment prematurely before 1 year. As assessed at 12 months, a bacteriologicalIy favourable response was achieved in 41% of 182 EMK(1), 43% of 195 EMK(2), 39% of 182 EMK(3) and 70% of 192 EMR. EMR regimen was significantly better than three EMK regimens. Bacteriological relapse rate calculated by Life Table method, in the second year of treatment was 13% in EMK(1), 22% in EMK(2), 20% in EMK(3) and 10% in EMR. The radiographic improvement was, on the whole, not significant. Adverse reactions were uncommon, 38 interrupted temporarily and 11 terminated their treatment completely due to adverse reactions.

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