Effect of Ethambutol on Carbohydrate meabolism in the Hen

Lee, Shin Woong; Bak, Jeung Ha; Cho, Kyu Park; Shim, Un Taek

doi:1978.25.3.108

Tuberc Respir Dis > Volume 25(3); 1978 > Article

Original Article

Tuberculosis and Respiratory Diseases 1978;25(3):108-114.
DOI: https://doi.org/10.4046/trd.1978.25.3.108 Published online September 1, 1978.

Effect of Ethambutol on Carbohydrate meabolism in the Hen

Shin Woong Lee¹, Jeung Ha Bak¹, Kyu Park Cho¹, Un Taek Shim²

¹Department of Pharmacology, Chungnam National University, School of Medicine, Daejeon, Korea
²Department of Preventive Medicine, Chungnam National University, School of Medicine, Daejeon, Korea

닭에서 Ethambutol이 탄수화물대사에 미치는 영향

이신웅¹, 박정하¹, 조규박¹, 심운택²

Abstract

The purpose of this study was to investigate the effect of ethambutol on the plasma glucose level of the unanesthized hen in both in vivo and in vitro experiments. Intravenous administration of ethambutol over the dose of 100 mg per kilogram of body weight elevated the plasma glucose level. Hyperglycemic effect of ethambutol was not inlluemed by epinephrin-einduced hy perglycemia, or regitine-, ergotamine-, alderlin-, and reserpinepretreatment. Alloxan-pretreatment and pancreatic ligation did not influence to ethambutol-induced hyperglycemia. Ethambutol increased the release of glucose from the hen liver slices, but did not affect the glycogen content of the isolated hen diaphragms in vitro. From the above results, it is suggested that hyperglycemic effect of large doses of intravenous ethambutol is due to the direct glycogenolytic action on the liver of the hen.