A Clinical Study on Thiacetazone in the Treatment of Pulmonary Tuberculosis in Korea

Pyun, Hae Won; Song, Ho Sung; Kim, Ki Ho; Song, Dal Ho; Kim, Sung Chin; Han, Yong Chul; Lee, Ki Yong; Bang, Ki Moon

doi:1971.18.1.5

Tuberc Respir Dis > Volume 18(1); 1971 > Article

Original Article

Tuberculosis and Respiratory Diseases 1971;18(1):5-11.
DOI: https://doi.org/10.4046/trd.1971.18.1.5 Published online March 1, 1971.

A Clinical Study on Thiacetazone in the Treatment of Pulmonary Tuberculosis in Korea

Hae Won Pyun, Ho Sung Song, Ki Ho Kim, Dal Ho Song, Sung Chin Kim, Yong Chul Han, Ki Yong Lee, Ki Moon Bang

Korean Institute of Tuoerculosis, The Korean National Tuberculosis Association, Seoul, Korea

Thiacetazone에 대한 임상적 연구

변해원, 송호성, 김기호, 송달호, 김성진, 한용철, 이기용, 방기문

Abstract

Introduction
In order to investigate efficacy, toxicity and side reactions of Thiacetazone to Korean patients, clinical study was conducted for 6 months at the five Institutions in Seoul, 1970.
Methods
The patients were selected at the health centers for those who were aged 15 years or more with previously untreated (if treated, not more than one month), sputum positive for tubercle bacilli and with no hepatic disorder at present or past. The total patients of 205 were treated with thiacetazone 150mg plus isoniazid 300mg daily and followed up for 6 months. Chest X-ray, Sputum examination for microscopy and culture, and blood examination including SGOT were carried out at 1,3,6, months after treatment beside initial examination for follow up.
Result
1) Out of 205 patients admitted to the study, side reactions were occurred in 66 cases (32.2%). By kind of side reactions, in account of frequency, skin rash 7.3%, nausea 2.9%, headache+rash 2.4%, headache 2%, nausea+vomiting 1.5%, and nausea+headache 1.0% 2) The patients who had to stop the regimen because of side reaction were 10.7% of the total patients. 3) Of the radiological changes, 69.2% of the patients showed improvement, 16.8% no change and 14% were deteriorated. 4) Sputum negative conversion rate was 23.9% at six months. 5) Drug resistance to thiacetazone were developed in 69.7% of the total patient who initially susceptible. At 6 month after treatment which is comparable to that of Isoniazid. 6) Pretreatment drug resistance to thiacetazone were observed in 60.5% of the total patients which are very high.

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