| The Clinical Evaluation of "PAS-ZID" Made in Korea |
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Okk Hee Yoo, Ki Ho Kim |
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Chest Clinic, Severance Union Medical College & Hospital, Seoul , Korea |
| 통원환자에 대한 국산「파스짓」사용보고 |
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유옥희, 김기호 |
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| Abstract |
INTRODUCTION
Nowadays, among the various chemotherapies for the treatment of tuberculosis, oral chemotherapy using INH and PAS is most popular. The clinical effects of combined chemotherapy using lNH-PAS are bridged in this report. As they were already reported at the preceding session of the conference under the title of "Clinical results
of oral chemotherapy for ambulatory tuberculous patients". This report, therefore, . merely refered to the clinical result of PAS-ZID administered to ambulatory tuberculous .patients in our chest clinic. We compared the clinical result of "PAS-ZID" with the combined chemotherapy of INH-PAS and the report from U. S. Public Health Service, published in ]an. 1954.
Before mentioning everything else, we must tell that: 1) The patients we observed were only 10 in all. These are too few to obtain a clinical evaluation of any drugs. 2) The period of administion ext eudiug to six months is too short to survey fully the condition of the chronic tuberculous patients. Consequently, this report ended in the partial observation of ten selected cases. We, also, think it is too early to announce the superiority of "PAS-ZID" in its general effect. One tablet of "PAS-ZID" consists of 0.5gm of PAS and 20 mgm of INH, and it is sugar -coated.
SUMMARY
1). We treated 10 ambulatory patients with pulmonary tuberculosis with homemade "PA S-ZID" for 24 weeks.
2). In the observation of X-ray findings, sputum and body-weight, ’'PAS-ZID" showed almost equal clinical improvement with other contrast groups. As for the frequency of conversion, "PAS-Z1D" showed a little be1.ter res-ult than other groups of oral chemotherapy Under the same condition.
3). There were no special disturbances of gastro-intestinal tract which are frequnently met in the course of PAS treatment.
4). Cases observed in this report was only 10 Patients and the duration was short. For the through and proper evaluation of the drugs, much more patients and ml1ch longer period of observation are necessary. |
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