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Tuberc Respir Dis > Volume 53(6); 2002 > Article
Original Article
Tuberculosis and Respiratory Diseases 2002;53(6):612-618.
DOI: https://doi.org/10.4046/trd.2002.53.6.612    Published online December 1, 2002.
The Effect of Midazolam As Sedative Agent in Bronchoscopy.
Sang Haak Lee, Dae Sung Hyun, Sook Young Lee, Seok Chan Kim, Young Kyoon Kim, Kwan Hyoung Kim, Hwa Sik Moon, Jeong Sup Song, Sung Hak Park
1Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea.
2Department of Internal Medicine, College of Medicine, Catholic University of Daegu, Korea. cmcksc@catholic.ac.kr
Abstract
BACKGROUND
Bronchoscopy is an important diagnostic and a therapeutic tool in chest medicine. However, most patients feel that a bronchoscopy is an unpleasant procedure, and it is important to sedate the patients appropriately, particularly where repetitive examinations are required. Midazolam is a sedative drug with amnestic qualities and a rapid 2 hour half-life. This study have attempted to determine the safety, appropriate dosage, and the effect of midazolam premedication in patients who underwent a bronchoscopy. METHODS: One hundred and eighty consecutive patients undergoing bronchoscopy were enrolled in this study. The patients received a midzolam doses of 0.03 mg/kg, 0.06 mg/kg, or a placebo. An additional dose of lidocaine, the total number of coughs, and the duration of the procedures were recorded with monitoring the the blood pressure, heart rate, and oxygen saturation. The level of satisfaction was assessed by the patient, bronchoscopist, and the nurse. RESULTS: The blood pressure, pulse rates, oxygen saturation, number of coughs, lidocaine dose, and procedure time in the 3 groups were similar. There was a trend for the midazolam 0.03 mg/kg group to satisfy bronchoscopists more than the other two groups. The nurses' acceptability was lower in the midazolam 0.06 mg/kg group than the other groups. The patients' acceptablity was greater in both the midazolam 0.03 mg/kg and 0.06 mg/kg groups than in the control group. CONCLUSION: Sedation with low doses of intravenous midazolam is a safe technique for fiberoptic bronchoscopy with a low morbidity and high acceptable to patients and bronchoscopists.
Key Words: Midazolam, Bronchoscopy, Sedation.Table 1, Patient characteristics (n=180)
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