| A Case of Lung Metastasis of Mesoblastic Nephroma in Adulthood. |
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Jin Wook Moon, Kil Dong Kim, Dong Hwan Shin, Chang Hoon Hahn, Jae Ho Jung, Mu Suk Park, Sang Youn Jung, Jae Hyuk Lee, Young Sam Kim, Se Kyu Kim, Sung Kyu Kim, Joon Chang |
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. chang@yumc.yonsei.ac.kr
2Department of Cardiovascular and Thoracic Surgery, Yonsei University College of Medicine, Seoul, Korea.
3Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
4The Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
5Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
6Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea. |
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| Abstract |
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Mesoblastic nephroma is a neoplasm of the kidney which is characterized by interlacing bundles of spindle mesenchymal cells. It is usually diagnosed during the first six months of life and is mostly benign. Incidence in adults is exceedingly rare. In most cases, only total excision is required without postoperative adjuvant therapy, and the rare cases of local recurrence have usually been related to incomplete removal. However, mesoblastic nephroma may behave aggressively, in contrast to a congenital mesoblastic nephroma. Several cases of metastatic mesoblastic nephroma have been previously described. We report herein a case of a 42-year-old woman with mesoblastic nephroma which recurred as a large metastatic lung mass seven years after the nephrectomy. The patient presented with chest wall discomfort for four days. Seven years previously, total nephrectomy had been performed because of a right renal tumor which had been diagnosed as a mesoblastic nephroma. There had been no evidence of recurrence for five years, after which she discontinued follow-up. On readmission two years later, chest X-ray and CT scan revealed a large lung mass in the left upper lobe. It was completely excised and the pathologic examination was identical with that of the original renal tumor. Synovial sarcoma was excluded because the fusion transcripts of the SYT-SSX fusion gene associated with the t(X;18) translocation were negative. The final diagnosis was a lung metastasis of mesoblastic nephroma and the patient remained free of disease for 7 months postoperatively. |
| Key Words:
Mesoblastic nephroma, Lung metastasis |
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