A Case of Primary Signet Ring Cell Carcinoma of Lung with Multiple Bone Metastasis.

Shin, Do Hyun; Kim, Hyoung Il; Lim, Seon Kyo; Lee, Seung Won; Jung, Youn Mu; Choi, Young In; Sheen, Seung Soo; Park, Joo Hun; Oh, Yoon Jung; Park, Kwang Joo; Hwang, Sung Chul; Park, Rae Woong; Shim, Chul

doi:2004.57.6.594

Tuberc Respir Dis > Volume 57(6); 2004 > Article

Case Report

Tuberculosis and Respiratory Diseases 2004;57(6):594-598.
DOI: https://doi.org/10.4046/trd.2004.57.6.594 Published online December 1, 2004.

A Case of Primary Signet Ring Cell Carcinoma of Lung with Multiple Bone Metastasis.

Do Hyun Shin, Hyoung Il Kim, Seon Kyo Lim, Seung Won Lee, Youn Mu Jung, Young In Choi, Seung Soo Sheen, Joo Hun Park, Yoon Jung Oh, Kwang Joo Park, Sung Chul Hwang, Rae Woong Park, Chul Shim

¹Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea. sssheen@ajou.ac.kr
²Department of Pathology, Ajou University School of Medicine, Suwon, Korea.

Abstract

Signet ring cell carcinoma of lung is an unique variant of mucin producing adenocarcinoma which is characterized by abundant intracellular mucin accumulation. Only a few cases of primary signet ring cell carcinoma of lung have been reported in the world wide literature. And we have, recently experienced one case of primary signet ring cell carcinoma of lung. A 55 years old man was evaluated for paralysis of lower extremities and was found to have lung cancer in the left upper and lower lobe with pleural, multiple spinal, bone and liver metastases. Signet ring tumor cells were revealed by cytologic examination of pleural fluids. And there were no evidence of signet ring cell carcinoma of other organs. Primary signet ring cell carcinoma of lung seems to have an aggressive behavior and therapeutic modalities could be different from those for signet ring cell carcinomas from other organs. Therefore it is important to separate primary signet ring cell adenocarcinoma of lung from metastatic tumors.

Key Words: Signet ring cell carcinoma, Lung cancer