A Study on the 2.3-DPG(Diphosphoglycerate) Activity in Red Blood Cells of the Patients with Bronchial Asthma, COPD (Chronic Obstructive Pulmonary Disease) and Pulmonary Tuberculosis |
Jeong Kwon Kim, Choong Seob Lee, Yong Chul Lee, Soo Yeong Lee, Ha Sook Song, Yang Geun Lee |
Department of Internal Medicine, Chonbuk National University College of Medicine, Chon Buk, Korea |
기관지 천식, 만성폐쇄성 폐질환, 폐결핵 환자의 적혈구내 2.3-DPG(Diphosphoglycerate)활성도에 대한 연구 |
김정권, 이충섭, 이용철, 이수영, 송하숙, 이양근 |
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Abstract |
Red blood cells synthesize 2.3- DPG that shifts the oxygen dissociation curve to right and consequently, increase the oxygen utilization and metabolism in the peripheral tissue. Recently there are many reports on the 2.3- DPG activity in red blood cell and related factor, ie PH, Temperature hemuglobin, anoxia, bicarbonate, and high altitude. On these fundament al basis. clinically 1 investigate the relationship between 2.3- DPG activity in red blood cell and known environmental factors in bronchial astsma, COPD and pulmonary tuberculosis.
The result doesn’t show significant change of 2.3-DPG activity according to each disease. its duration, and its severity. But, it shows a correlation between 2.3- DPG activity and environmental fact ors‘ Especially a arterial oxygen partial pressure shows a reverse correlation with 2.3-DPG activity. These results suggest that 2.3-DPG activity mainly depends on the arterial oxygen partial pressure. |
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