A Pilot Study of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease.

Bae, Yun Oh; Han, Min Soo; Lee, Seong Kyu; Kim, Jeong Nyum; Kim, Jeong Sik; Kim, Jinho; Cho, Yongseon; Lee, Yang Deok

doi:2003.54.4.395

Tuberc Respir Dis > Volume 54(4); 2003 > Article

Original Article

Tuberculosis and Respiratory Diseases 2003;54(4):395-402.
DOI: https://doi.org/10.4046/trd.2003.54.4.395 Published online April 1, 2003.

A Pilot Study of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease.

Yun Oh Bae, Min Soo Han, Seong Kyu Lee, Jeong Nyum Kim, Jeong Sik Kim, Jinho Kim, Yongseon Cho, Yang Deok Lee

Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. hms43@freechal.com

Abstract

BACKGROUND
Patients with chronic obstructive pulmonary disease (COPD) are at increased risk for osteoporosis, which has implications for mobility and even mortality. The goal of this pilot study was to evaluate bone mineral density (BMD) and risk factors for osteoporosis in a limited number of men with COPD. METHODS: We checked BMD, FEV1(% of predicted) and investigated risk factors for osteoporosis in 44 male patients with COPD who visited our hospital from January to August 2002. RESULTS: Mean(+/-) age was 69+/-9 yrs, body mass index(BMI) 21+/- 3 kg/m2, FEV1 50+/- 18% of predicted, lumbar spine T-score -3.0+/- 1.2, lumbar spine Z-score -2.0+/-1.2, and lumbar spine BMD 0.76 +/-0.13 g/cm2. Osteoporosis(T-score below -2.5) was present in 27 patients(61.4%) and osteopenia(T-scorebetween -1 and -2.5) in 17(38.6%). None of the patients had normal BMD. There was no relationshipbetween BMD and FEV1(% of predicted). There were significant differences in smoking, alcohol consumption, exercise, cumulative steroid dose, BMI and BMD among the three groups according to FEV1(% of predicted) (group1 : > or =65%, group2 : 50-64%, group3 : < or =49%), except age. However, there were no significant differences in these variables between the osteopenia and osteoporosis groups, except BMI. Linear Regression(Stepwise) analysis showed that lumbar BMD was correlated with BMI & exercise. CONCLUSION: BMD is significantly reduced in men with COPD. There was no relationship between BMD and pulmonary function.

Key Words: Osteoporosis, Chronic obstructive pulmonary disease, Bone mineral density