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Tuberc Respir Dis > Volume 66(3); 2009 > Article
Tuberculosis and Respiratory Diseases 2009;66(3):186-191.
DOI: https://doi.org/10.4046/trd.2009.66.3.186    Published online March 1, 2009.
Prevalence and Risk Factors of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease.
Yun Su Sim, , Jin Hwa Lee, , Yon Ju Ryu, , Eun Mi Chun, , Jung Hyun Chang,
1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. jinhwalee@ewha.ac.kr
2Clinical Research Center for Chronic Obstructive Airway Diseases, Seoul, Korea.
Abstract
BACKGROUND
Osteoporosis is a significant comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study examined the prevalence and risk factors associated with osteoporosis in patients with COPD. METHODS: The bone mineral densities (BMDs) of the lumbar spine and femoral bone were measured in 53 patients with clinically stable COPD and 41 age- and gender-matched control subjects showing a normal lung function. Osteoporosis was defined as a T-score < or =-2.5. The subjects' clinical characteristics and laboratory data were reviewed, and multiple logistic regression analysis was used to identify the risk factors associated with osteoporosis in COPD patients. RESULTS: The prevalence of osteoporosis was 47% and 32% in the COPD patients and controls, respectively. In particular, using the femoral neck T-score, the prevalence of osteoporosis in COPD patients was higher than that in the controls (26% vs. 5%; p=0.006). The average T-score of the lumbar spine (p=0.025) and femoral neck of COPD patients were significantly lower than those of the controls (p=0.001). The forced expiratory volume in the 1 second (FEV1) % predicted (p=0.019; odds ratio [OR], 0.955; 95% confidence interval [CI], 0.919-0.993) and age (p=0.024; OR, 1.144; 95% CI, 1.018-1.287) were independently associated with osteoporosis in patients with COPD. CONCLUSION: Using the femoral neck T-score, the prevalence of osteoporosis in patients with COPD was higher than the age-and gender-matched controls. A lower FEV1 and older age further increase the risk of osteoporosis in patients with COPD.
Key Words: Chronic obstructive pulmonary disease, Osteoporosis, Prevalence, Risk factor, Lung function


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