A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer. |
Young Il Kim, Kyu Sik Kim, Eui Ryoung Han, Yong Soo Kwan, In Jae Oh, Sung Chul Lim, Young Chul Kim |
1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea. cyberkks@chonnam.ac.kr 2Department of Internal Medicine, Division of Allergy, Asthma and Clinical Immunology, Chonnam National University Medical School, Gwangju, Korea. |
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Abstract |
Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis. |
Key Words:
Etoposide, Anaphylaxis, Small cell lung carcinoma, Skin tests |
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