Tuberc Respir Dis > Volume 67(2); 2009 > Article
Tuberculosis and Respiratory Diseases 2009;67(2):145-147.
DOI: https://doi.org/10.4046/trd.2009.67.2.145    Published online August 1, 2009.
A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer.
Young Il Kim, Kyu Sik Kim, Eui Ryoung Han, Yong Soo Kwan, In Jae Oh, Sung Chul Lim, Young Chul Kim
1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea. cyberkks@chonnam.ac.kr
2Department of Internal Medicine, Division of Allergy, Asthma and Clinical Immunology, Chonnam National University Medical School, Gwangju, Korea.
Abstract
Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.
Key Words: Etoposide, Anaphylaxis, Small cell lung carcinoma, Skin tests


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