A Case of Henoch-Schonlein Purpura Developed during Treatment of Lung Cancer.

Kang, Min Soo; Noh, Geum Yeub; Jang, Young Joo; Cho, Soo Youn; Rhim, Kyung Jin; Noh, Hee Sun; Kim, Hye Ryoun; Kim, Cheol Hyeon; Lee, Jae Cheol

doi:2009.67.3.234

Tuberc Respir Dis > Volume 67(3); 2009 > Article

Case Report

Tuberculosis and Respiratory Diseases 2009;67(3):234-238.
DOI: https://doi.org/10.4046/trd.2009.67.3.234 Published online September 1, 2009.

A Case of Henoch-Schonlein Purpura Developed during Treatment of Lung Cancer.

Min Soo Kang, Geum Yeub Noh, Young Joo Jang, Soo Youn Cho, Kyung Jin Rhim, Hee Sun Noh, Hye Ryoun Kim, Cheol Hyeon Kim, Jae Cheol Lee

¹Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea. jclee@kcch.re.kr
²Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
³Department of Dermatology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.

Abstract

Henoch-Schonlein Purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA and C3, which is characterized by associated skin, joint, renal, and gastrointestinal manifestations. Although there were several causes such as autoimmunity, infection, and drugs, it also can be presented as a form of vasculitidies associated with malignancies. We report a case of HSP developed during treatment for non-small cell lung cancer in a 66-year-old man. Multiple purpuric skin lesions occurred in both legs after the first cycle of chemotherapy, which was diagnosed as HSP by clinical and pathologic examinations. Due to the itching sensation, topical steroid was applied and the patient was improved 3 weeks later without a scheduled change in chemotherapy.

Key Words: Lung neoplasms, Henoch-Schonlein purpura, Vasculitis