A Case of Acute Eosinophilic Pneumonia Associated with Intramuscular Administration of Progesterone Following In Vitro Fertilization.

Park, Sung Keun; Choi, Byoung Ho; Chon, Su Yeon; Kim, Yu Jin; Kyung, Sun Young; Lee, Sang Pyo; Jeong, Sung Hwan; Park, Jeong Woong

doi:2009.67.6.556

Tuberc Respir Dis > Volume 67(6); 2009 > Article

Case Report

Tuberculosis and Respiratory Diseases 2009;67(6):556-559.
DOI: https://doi.org/10.4046/trd.2009.67.6.556 Published online December 1, 2009.

A Case of Acute Eosinophilic Pneumonia Associated with Intramuscular Administration of Progesterone Following In Vitro Fertilization.

Sung Keun Park, Byoung Ho Choi, Su Yeon Chon, Yu Jin Kim, Sun Young Kyung, Sang Pyo Lee, Sung Hwan Jeong, Jeong Woong Park

Department of Internal Medicine, Gachon University of Medicine and Science, Incheon, Korea. jwpark@gilhospital.com

Abstract

Acute eosinophilic pneumonia (AEP) is characterized by idiopathic acute febrile illness, diffuse pulmonary infiltration, severe hypoxemia, and pulmonary eosinophilia. We report a case of AEP associated with intramuscular administration of progesterone as luteal phase support after in vitro fertilization. A 33-year-old woman presented to our emergency room with tachypnea and hypoxemia, complaining of fever and cough for 4 days, and dyspnea for 2 days. The symptoms began 9 days after the first injection of progesterone. Chest radiograph showed bilateral infiltrates, located predominantly in the periphery of the lungs, with blunting of the costophrenic angle. Symptoms and chest radiograph dramatically improved after corticosteroid therapy and shifting the progesterone from an intramuscular form of administration to a vaginal form of administration.

Key Words: Pulmonary Eosinophilia, Progesterone, Eosinophilia