A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion.

Kim, Hyun Kyung; Kim, Su Woo; Kang, Hye Won; Kwon, Kyoung Joo; Park, Hye Sung; Ryu, Yon Ju; Lee, Jin Hwa; Chun, Eun Mi; Cho, Young Joo; Chang, Jung Hyun

doi:2010.68.5.294

Tuberc Respir Dis > Volume 68(5); 2010 > Article

Case Report

Tuberculosis and Respiratory Diseases 2010;68(5):294-297.
DOI: https://doi.org/10.4046/trd.2010.68.5.294 Published online May 1, 2010.

A Case of Delayed Severe Hypersensitivity Reaction during Genexol-PM(R) Infusion.

Hyun Kyung Kim, Su Woo Kim, Hye Won Kang, Kyoung Joo Kwon, Hye Sung Park, Yon Ju Ryu, Jin Hwa Lee, Eun Mi Chun, Young Joo Cho, Jung Hyun Chang

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. hs1017@ewha.ac.kr

Abstract

Although Taxol(R) is one of the most successful drugs in current cancer chemotherapy against solid tumors, a major problem is hypersensitivity reactions that arises as a consequence of activation of the complement (C) system, "C activation-related pseudo-allergy". Most severe hypersenstivity reactions occur within the first few minutes of Taxol(R) administration, usually after the first or second dose. Here we report a case of a severe hypersensitivity reaction in a 72-year-old man undergoing Genexol-PM(R) infusion. Hypotension and polymorphic pruritic skin rash appeared 2 hours after the start of Genexol-PM(R) infusion (with an appropriate premedication). Treating with methylprednisolone, epinephrine and inotropic agents, reduced the hypotension and the skin rash disappeared. We report this case with a review of the literature.

Key Words: Hypersensitivity, Delayed, Anaphylaxis, Purpura, Paclitaxel