A Case of Trousseau's Syndrome with Catastrophic Course Triggered by an Intravenous Injection.

Moon, Ji Yong; Kim, Sa Il; Kwak, Hyunjung; Song, Soon Young; Kim, In Soon; Kim, Sang Heon; Kim, Tae Hyung; Sohn, Jang Won; Yoon, Ho Joo; Shin, Dong Ho; Park, Sung Soo

doi:2011.71.2.134

Tuberc Respir Dis > Volume 71(2); 2011 > Article

Case Report

Tuberculosis and Respiratory Diseases 2011;71(2):134-138.
DOI: https://doi.org/10.4046/trd.2011.71.2.134 Published online August 1, 2011.

A Case of Trousseau's Syndrome with Catastrophic Course Triggered by an Intravenous Injection.

Ji Yong Moon, Sa Il Kim, Hyunjung Kwak, Soon Young Song, In Soon Kim, Sang Heon Kim, Tae Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park

¹Department of Internal Medicine, Hanil General Hospital, KEPCO Medical Foundation, Seoul, Korea.
²Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. shindh@hanyang.ac.kr
³Department of Radiology, Hanyang University College of Medicine, Seoul, Korea.

Abstract

Trousseau's syndrome is an unexplained thrombotic event that precedes the diagnosis of an occult visceral malignancy or appears concomitantly with the tumor. Upper extremity deep vein thrombosis is prevalent in patients with a central venous catheter. Furthermore, a peripheral intravenous injection may cause upper extremity deep vein thrombosis as well. However, a deep vein thrombosis has not been reported in the form of Trousseau's syndrome with a catastrophic clinical course triggered by a single peripheral intravenous injection. A 48-year-old man presented with a swollen left arm on which he was given intravenous fluid at a local clinic due to flu symptoms. Contrast computed tomgraphy scans showed thromboses from the left distal brachial to the innominate vein. The patient developed multiple cerebral infarctions despite anticoagulation treatment. He was diagnosed with stomach cancer by endoscopic biopsy to evaluate melena and had a persistently positive lupus anticoagulant. After recurrent and multiple thromboembolic events occurred with treatment, he died on day 20.

Key Words: Upper Extremity Deep Vein Thrombosis, Antiphospholipid Syndrome, Stomach Neoplasms