Tuberc Respir Dis > Volume 72(1); 2012 > Article
Tuberculosis and Respiratory Diseases 2012;72(1):72-76.
DOI:    Published online January 1, 2012.
A Case of Primary Lung Cancer Producing Alpha-fetoprotein.
Ji Hyun Yu, Joong Hyun Ahn, Han Hee Chung, Young Wook Kim, Jin Sok Yu, Ju Sang Kim
Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea.
We observed a very rare case of primary lung cancer producing alpha-fetoprotein (AFP). A 70-year-old male with a history of smoking 50 packs per year was diagnosed with large cell carcinoma of the lung. The clinical stage was T2bN3M0 (IIIB), and serum AFP was 23,247 ng/mL. There was no evidence of metastasis to the liver, scrotum or other organs. While undergoing chemotherapy for 1 year, as the cancer progressed the AFP value steadily increased. The patient died of respiratory failure due to pneumonia 12 months after being diagnosed with lung cancer.
Key Words: alpha-Fetoproteins, Lung Neoplasms, Carcinoma, Large Cell

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