Tuberc Respir Dis > Epub ahead of print
DOI: https://doi.org/10.4046/trd.2022.0053    [Epub ahead of print]
Published online June 20, 2022.
Post–Coronavirus Disease 2019 Pulmonary Fibrosis: Wait or Needs Intervention
Hee-Young Yoon, M.D., Ph.D.  , Soo-Taek Uh, M.D., Ph.D. 
Division of Allergy and Respiratory Diseases, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea
Correspondence:  Soo-Taek Uh, Tel: 82-2-709-9195, Fax: 82-2-709-9083, 
Email: uhs@schmc.ac.kr
Received: 22 April 2022   • Revised: 25 May 2022   • Accepted: 15 June 2022
Abstract
Coronavirus disease 2019 (COVID-19) has become a major health burden worldwide, with over 450 million confirmed cases and 6 million deaths. Although the acute phase of COVID-19 management has been established, there is still a long way to go to evaluate the long-term clinical course or manage complications due to the relatively short outbreak of the virus. Pulmonary fibrosis is one of the most common respiratory complications associated with COVID-19. Scarring throughout the lungs after viral or bacterial pulmonary infection have been commonly observed, but the prevalence of post– COVID-19 pulmonary fibrosis is rapidly increasing. However, there is limited information available about post–COVID-19 pulmonary fibrosis, and there is also a lack of consensus on what condition should be defined as post–COVID-19 pulmonary fibrosis. During a relatively short follow-up period of approximately 1 year, lesions considered related to pulmonary fibrosis often showed gradual improvement; therefore, it is questionable at what time point fibrosis should be evaluated. In this review, we investigated the epidemiology, risk factors, pathogenesis, and management of post–COVID-19 pulmonary fibrosis.
Key Words: Coronavirus Disease 2019, Pulmonary Fibrosis, Complications, Incidence, Pathogenesis, Prognosis, Treatment


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