Tuberc Respir Dis > Epub ahead of print
Interstitial Lung Diseases
DOI: https://doi.org/10.4046/trd.2021.0025    [Epub ahead of print]
Published online May 20, 2021.
Korean Guidelines for Diagnosis and Management of Interstitial Lung Diseases: Part 4. Cryptogenic Organizing Pneumonia
Sue In Choi, M.D., Ph.D  , Won Jai Jung, M.D., Ph.D, Eun Joo Lee, M.D., Ph.D 
Division of Respiratory, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea
Correspondence:  Eun Joo Lee, Tel: +82 2 920 5048, Fax: +82 2 929 2045, 
Email: nanjung@korea.ac.kr
Received: 7 February 2021   • Revised: 11 April 2021   • Accepted: 19 May 2021
Abstract
Cryptogenic organizing pneumonia (COP) is a type of idiopathic interstitial pneumonia with an acute or subacute clinical course. Bilateral lung consolidations located in the subpleural area and bronchovascular bundle are the most common findings on chest high-resolution computed tomography. The pathologic manifestations include granulation tissue in the alveoli, alveolar ducts, and bronchioles. COP responds fairly well to glucocorticoid monotherapy with rapid clinical improvement, but recurrence is common. However, treatment with combined immunosuppressant agents is not recommended, even if the COP patient does not respond to glucocorticoid monotherapy with expert opinion.
Key Words: Cryptogenic Organizing Pneumonia, Glucocorticosteroid, High-Resolution Computed Tomography


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