Cefotiam Concentrations in Bronchial Secretions

Kim, W. S.; Chung, H. S.; Kim, Y. W.; Han, S. K.; Shim, Y. S.; Kim, K. Y.; Han, Y. C.; Shin, B. M.; Kim, E. C.

doi:1988.35.4.251

Tuberc Respir Dis > Volume 35(4); 1988 > Article

Original Article

Tuberculosis and Respiratory Diseases 1988;35(4):251-255.
DOI: https://doi.org/10.4046/trd.1988.35.4.251 Published online December 1, 1988.

Cefotiam Concentrations in Bronchial Secretions

W. S. Kim¹, H. S. Chung¹, Y. W. Kim¹, S. K. Han¹, Y. S. Shim¹, K. Y. Kim¹, Y. C. Han¹, B. M. Shin², E. C. Kim²

¹Department of Internal Medicine and Tuberculosis Research lnstitute, College of Medicine, Seoul National University, Seoul, Korea
²Department of Clinical Pathology, College of Medicine, Seoul National University, Seoul, Korea

기관지감염 환자에서의 기관지분비물내 Cefotiam 농도

김우성¹, 정희순¹, 김영환¹, 한성구¹, 심영수¹, 김건열¹, 한용철¹, 신보문², 김의종²

Abstract

The penetration of cefotiam into bronchial secretions was evaluated in 20 patients with acute bacterial infections after administration of a single intravenous dose of cefotiam 1 g. Bronchial secretions were aspirated bronchoscopically, in 1, 2, 3 & 4 hours after cefotiam infusion and serum was sampled simultaneously. Cefotiam concentrations were measured by thin layer cup methods. Cefotiam concentrations in bronchial secretions were 2.2, 2.5, 2.2, 3.3 mcg/ ml at 1, 2, 3 and 4 hours, respectively, which were higher than minimum inhibitory concentrations for E . coli, K. pneumonia, H. influenza & P. mirabilis. The ratios of the cefotiam concentration in the bronchial secretion to that in the serum at the same tirne were 0.70 and 1.27 in 3 & 4 hours. The results confirm the rapid and significant diffusion of cefotiam into the bronchial secretion, especially in the presence of acute bacterial infection.