Site of Airway Obstruction and Localization of Bronchodilator Response in Asthma

Yoon, Hyun Koo; Choi, Hak Rhim; Yoo, Jee Hong; Kang, Hong Mo; Kim, Won Dong

doi:1987.34.2.144

Tuberc Respir Dis > Volume 34(2); 1987 > Article

Original Article

Tuberculosis and Respiratory Diseases 1987;34(2):144-149.
DOI: https://doi.org/10.4046/trd.1987.34.2.144 Published online June 1, 1987.

Site of Airway Obstruction and Localization of Bronchodilator Response in Asthma

Hyun Koo Yoon, Hak Rhim Choi, Jee Hong Yoo, Hong Mo Kang, Won Dong Kim

Department of Intemal Medicine, Kyung Hee University, School of Medicine, Seoul, Korea

기관지천식에서 기도폐색부위에 관한 연구

윤현구, 최학림, 유지홍, 강홍모, 김원동

Abstract

ln order to determine the relationship between the major sites of airflow limitation and bronchodi1ator action. we studied helium response before and after the administration of bronchodi1ator in 23 asthmatics. Our results were as follows; 1) ln the 23 asthmatics. there were 16 responders and 7 nonresponders. 2) After bronchodi1ator. 13 responders remained responders and 4 nonresponders became responders. 3) A highly significant correlation was noted between prebronchodilator values of FEF 50% (air) and FEF 50% (He-O₂). 4) A significant inverse correlation was present between prebronchodilator values of ΔFEF 50% and the incremental or decremental changes in ΔFEF 50% postbronchodilator [Δ(Δ FEF 50%)]. This study suggests that the patients with severe degree of obstruction in asthma tend to have airflow limitation in the peripheral airways and the predominant sites of bronchodi1atation in asthmatics are related to the prebronchodi1ator obstructive sites.