Effect of Smoking on Secretory IgA in Bronchoalveolar Lavage Fluid |
I. H. Kim, C. H. Kim, D. H. Yang, S. Y. Ahn, C. S. Park |
Department of Internal Medicine, Soon Chun Hyang University Hospital, Seoul, Korea |
흡연에 의한 기관지폐포 세척액 내의 분비형 IgA의 동향 |
김인호, 김치환, 양동호, 안상용, 박춘식 |
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Abstract |
Synthesis of S-IgA in bronchial tree is dependent on the epithelial cell function, which could be influenced by smoking. To evaluate the effect of smoking on bronchial epithelium and the value of S-IgA to differentiate malignancy from benign lung diseases, S-IgA was measured in the bronoalveolar lavage fluid of 34 patients with lung cancer and pulmonary tuberculosis.
The results were as follows:
1) S-IgA concentration of BAL fluid is 2.61± 1.93 flg/m1 in smokers compared with 5.26 ±3.66 μg/ml in nonsmokers(p<0.025).
2) There was no difference of S-IgA concentration in BAL fluid not only between cancer-smoker group and tuberculosis-smoker group but also between cancer-nonsmoker group and tuberculosis-nonsmoker group.
3) Serum S-IgA concentration of smokers is not different from that of nonsmoker.
4) The ratio of S-IgA to albumin in BAL fluid to S-IgA to albumin in serum is above 1.0 in all cases and that smokers is not different from that of nonsmokers.
In conclusion, the smoking causes S-IgA synthesis in bronchial tree to diminish and S-IgA measurement in serum and BAL fluid have no diagnostic value to differentiate malignant disease from Benign lung disease. |
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