Introduction
Tobacco smoking is an important contributor to respiratory disease, including chronic obstructive pulmonary disease (COPD) and lung cancer, cardiovascular disease, and cancers of various organs. Tobacco smoking also negatively affects several other respiratory diseases, including pneumonia and pulmonary tuberculosis
1. Therefore, smoking cessation is a practical way to prevent and treat smoking-related disease. In Korea, the adult male smoking rate was 66.3% in 1998; however, increased interest in health and a smoking cessation promotion policy, resulted in a reduction in this figure to 47.7% in 2008. However, that has been at a standstill since 2008, with 47.3% in 2011
2. The reason for the high smoking rate among males, despite the well-known harmfulness of smoking, is attributable to addiction caused by nicotine contained in cigarettes. Thus, it is necessary to perceive smoking as a disease that should be managed and treated as a drug addiction or chronic diseases rather than as a personal habit or hobby
3.
Smoke cessation programs currently in effect are divided into pharmacotherapies and behavioral therapies or combinations thereof. Effective pharmacotherapies for smoking cessation include nicotine replacement therapy (NRT), bupropion or nortriptyline, and varenicline. Use of these forms of therapies increases quit rates 1.5- to 2.5-fold, and is a potentially valuable adjunct to any advice provided
4. Until now, most domestic research on the effects of smoking cessation programs focused on effectiveness of the pharmacotherapy and targeted healthy adults who have decided to quit smoking
5. Brief advice or counseling given by physicians to patients can strong and cost-effective smoking cessation program, can reduce morbidity and mortality
4. Unfortunately, many smokers who see physicians do not receive assistance to quit. Accordingly, this study was conducted on patients who were encouraged to quit smoking, offered advice, and provided manners for smoking cessation by a pulmonologist at every outpatient session to investigate the 6-month continuous abstinence rate and to analyze the factors that influence the success rate.
Materials and Methods
This study was conducted on 126 subjects who visited the Division of Pulmonology of Seoul Medical Center from May 2011 to March 2012. All 126 subjects had been smoking more than five cigarettes per day and followed up for more than six months. The self-reported questionnaire with the Fagerstöm Test for Nicotine Dependence (FTND) was administered to the daily smokers at first visit. The FTND has six items with an overall score ranging between 0 and 10. In this study, high dependence was defined as a FTND score≥8 (low 0-3, moderate 4-7)
6,7. The standardized questionnaire was included with their smoking history (including pack-years, starting age, previous quitting attempts, smoking-related and unrelated diseases, and motivational aspects of quitting), alcohol habit, educational level, marriage status, number of family members, pulmonology history (chief complaint at the time of the first visit, admission or not, final diagnosis and pulmonary disease status), and presence of underlying diseases including cardiovascular diseases, hypertension, diabetes, chronic kidney disease, malignancy and psychiatric diseases. Subject's height, weight, body mass index (BMI), pulmonary function test and chest radiograph were taken. Also, in the group aged >50 years and >20 pack-years were taken low dose chest computed tomography (CT) scans for lung cancer screening.
A pulmonologist provided motivation of smoking cessation according to modified forced expiratory volume at 1 second (FEV
1) percentage by patient's age and disease status. The pulmonologist also presented a short lecture on nicotine dependence; syndromes of nicotine withdrawal; harmful effects of smoking and the benefits of quitting; how to handle weight gain and how to avoid trigger situations. The subjects were educated to know that smoking is a disease caused by nicotine addiction via multimedia and were provided with a medical handbook about smoking cessation made by our hospital. At each visit during the study period, motivational aspects, identification of triggers, management of weight gain, and use of medication were discussed for a mean time of 10 minutes. In addition, if the patient agrees, additional counseling for more than 30 minutes at first visit, telephone follow-up, and regular advice were also provided by the trained practical nurse. Regardless of this, all participants received one of three interventions; 1) motivational interviewing (MI) only, 2) MI with NRT-free offer, or 3) MI with varenicline (
Figure 1).
The primary outcome considered was continuous smoking abstinence rate, which was evaluated at 6, 12, and 24 weeks. Smoking cessation success was defined as a subject orally reporting that he or she had not smoked at all for 6 months or longer, and for whom the result of exhaled CO level was consistently <10 ppm. We also studied the factors associated with continuous abstinence for 6 months or longer, including age, sex, educational level, marriage status, nicotine dependence, number of cigarettes smoked per day, and comorbidities. This study was approved by the Institutional Review Board at Seoul Medical Center. All subjects provided written informed consent.
Data analyses were performed using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA). Pearson's chi-square test for categorical variables and a two sample t-test for continuous variables were used to test the baseline differences between the success and failure groups. A logistic regression model was used for the analysis of factors affecting the success of 6-month smoking cessation. The level of significance was established at α=0.05.
Discussion
Tobacco smoking is an important contributor to respiratory diseases; it is the major etiological factor for the development of COPD and lung cancer, and adversely affects control of asthma
1. Smoking cessation is the most important intervention in COPD and respiratory disease, so it is important that pulmonary physicians act to ensure that patients with COPD and other respiratory diseases quit smoking.
In present study, the continuous smoking abstinence rates was 55.6%, 47.6%, and 33.3% at 6 weeks, 3 months, and 6 months, respectively. In one randomized clinical trial of transdermal nicotine patches in Korea, contrary to the point prevalence abstinence rates (20.3% at 3-month and 24.6% at 6-month follow-up), the continuous abstinence rates decreased linearly as follows: 20.3% at 3-month follow-up and 17.8% at 6-month follow-up
8. The other studies with varenicline in Asia revealed that their success rates of 6-month smoking cessation were 37.7%
9, 46.8%
10, and 50.3%
11. However, these randomized, placebo-controlled trials may not reflect the clinical practice, and in smokers that had actually visited an outpatient department, the motivation and readiness to quit could be different from smokers at smoking cessation clinics. Other researchers have estimated that only 3-5% of smokers are able to achieve prolonged abstinence for 6-12 months after a given unassisted quit attempt, an estimate consistent with the high levels of failure
12.
The subjects of this study were patients seeking an outpatient department of pulmonology, with relatively low education level (equal to and lower than those of a middle school diploma in 52.4%), and low income level (34.1% were patients with medical assistance and homeless) from a socioeconomic point of view, and with brief smoking cessation intervention program in practice with low rate of prescribing medications (only 11.9% of patients used varenicline). Thus, it is likely that the success rate of 6-month continuous smoking abstinence was not low in the subjects of this study due to more experiences in abnormal symptoms and signs, and stronger motivation for smoking cessation by diagnosing of disease or having biofeedback of their FEV1 %.
One promising approach to encourage cessation among less motivated smokers is motivational interviewing
13. Motivational interviewing is a patient-centered directive approach to enhance intrinsic motivation to behavioral change by helping patients explore and resolve ambivalence between the desired behavior and their actual behavior
14,15. It focuses on what patients can do to improve their own health, as opposed to health care providers telling them what to do
14. Ojedokun et al.
16 reported that, in addition to brief cessation support during routine consultations, providing lung age biofeedback to smokers along with pharmacotherapy significantly increased (control 12.0% vs. intervention 22.1%), the proportion who quit within a month. In the present study, when promoting smoking cessation during clinical consultations, we provided the 'percentage of FEV
1 compared with predictive value based on their age, height and ethnicity' biofeedback to patients, and 'extent of emphysema and bronchial wall thickening' also to the patients who underwent low-dose CT scans of chest.
However, in the present study, the degree of FEV
1 % or the presence of abnormal findings on chest low-dose CT scans were not significant factors affecting the success rate of 6-month smoking cessation. We suggest that these factors could be helpful in motivational aspects of smoking cessation, but not in maintenance of cessation of smoking. Nevertheless, it is widely believed that planning for a difficult task like quitting smoking should result in increased success
17. In addition, there is some evidence that smokers may be more receptive to advice to stop when it is linked with an existing medical condition (not necessarily smoking-related)
18. However, until now, encouraging and supporting smoking cessation appears to be a low priority among physicians, even though this intervention is highly cost-effective and is the only intervention that reduces the risk of developing respiratory diseases and slows its progression. In this study, we were able to achieve the favorable continuous smoking abstinence rate by motivational interviewing with screening or diagnosing tool for lung diseases and continuous brief support for smoking cessation during every routine consultations. In some healthcare settings, they can also refer people to more intensive behavioral counseling and support, either face-to-face or via telephone quit line services
4,19. However, the present study did not convincingly demonstrate that more intensive counseling from a practice nurse could increase cessation rates amongst smokers.
Several studies have shown that the main predictors of smoking cessation are age, gender, the daily consumption of tobacco, marital status (living with a spouse or partner), stress, social status, baseline motivation to stop smoking, nicotine dependency (FTND), and so on
20,21. In the univariable logistic regression analysis of our study, we found that the number of cigarettes per day, degree of FTND, a will to quit smoking, the absence of psychiatric disease and smoking-related lung disease, the history of admission, education level, and prescription of varenicline and NRT were significant predictors for smoking cessation at 6-month follow-up. In this study, we could not check the income level of the patients; however, there was no difference according to the type of insurance or homeless status. Nevertheless, the patients with history of hospitalization showed more favorable results of the smoking cessation, because hospitalization may be a potentially powerful "teachable moment" in which smokers are often motivated to quit and are receptive to assistance due to concerns about their health
22.
Although the prescription of varenicline or NRT was a factor related to 6-month smoking cessation, no significant difference was found in multivariate logistic regression analysis. Data from numerous randomized controlled trials demonstrate clearly the effectiveness of NRT, bupropion and varenicline in promoting long-term abstinence from smoking
23. Possible explanation for the finding of lower effectiveness in the "real practice" is that many smokers fail to adhere to treatment recommendations
23,24. Particularly, NRT was given free of charge every 2 weeks; it might be helpful for motivational aspect, through it was possible that the patients spontaneously discontinued treatment. In addition, for varenicline, due to drug cost, adverse events, and drug incompliance, 12-week varenicline treatment was rarely conducted, especially in public hospital with patients with low economic status. In fact, only 7 subjects (of 15) took varenicline for longer than 2 weeks (median, 3 weeks; range, 1-12 weeks) through their success rate was higher (5 of 7, 71.4%) than the 0% of the group that terminated varenicline treatment early.
In multivariate logistic regression analysis, degree of FTND, the absence of smoking-related lung disease, and education level were the predictors of successful smoking cessation. The FTND, a non-invasive and easy-to-obtain self-reported tool that conceptualizes dependence through physiological and behavioral symptoms, is used for assessing nicotine dependence
7. In our study, the majority of the patients in the 6-month smoking cessation group had low to moderate (0-7) dependency in the FTND. In addition, smoking cessation rate was much lower in the patients with smoking-related lung disease. Although patients with respiratory disease have a greater and more urgent need to stop smoking than the average smoker, many often find it more difficult to do so. In one randomized controlled trial (RCT), 26 week-continuous abstinence rates of smokers with mild or moderate COPD were 16% in bupropion group, and 9% in placebo group
25. Some smokers succeed in quitting and, thus, drop out of the smoking population, but the majority fail. It follows from this selection hypothesis that the more severe the lung disease, the more difficult it is to give up smoking
1. Another factor that can contribute to the difficulties faced by respiratory patients who smoke is the relatively high prevalence of depression or low mood
1.
Many smokers would prefer to reduce the number of cigarettes smoked daily rather than quitting completely. In several RCTs of smoking reduction, a reduction in daily cigarette smoking of 50% after 3-4 months had a strong predictive value for quitting at 1 year (a reduction in daily cigarette smoking in 15.9% of smokers using NRT vs. 6.7% using placebo → smoking cessation rates after 1 year in 8.4% among NRT users vs. 4.1% in placebo users)
1. In this study, tobacco consumption was decreased to under 10 cigarettes per day in 42.1% (53/126), and in 22.2%, tobacco consumption was kept under five cigarettes per day. Their tobacco consumption decrement was an average of 13.2±9.7 cigarettes per day (21.4±8.3 at the time of the first visit → 8.2±9.1 after 6 months cigarettes per day). The smoking reduction concept should be offered to patients with respiratory disorders who smoke and who are not motivated to quit
1. Smoking reduction seems to have a role for smokers not currently motivated or able to quit as a gateway to complete cessation; however, we cannot conclude that a reduction in daily cigarette smoking leads to smoking cessation at long term follow-up.
Additional limitation of this study include that it used data from only one outpatient clinic in public hospital; the results, therefore, need to be confirmed by more studies. In addition, this is a retrospective observational study that was conducted on patients seeking an outpatient department of pulmonology, there are many volatile variables, such as the number of visits, the timing of diagnosed of respiratory disease, and the use of respiratory medicines, etc. In addition, it does not analyze withdrawal symptoms or gained weight, and adverse events of prescribed drugs, and used dosage of NRT or varenicline in "real-world." As varenicline was not provided free of charge, subjects had to purchase them themselves on prescription, while NRT was provided free of charge. Additionally, the number of cigarettes of patients smoking per day was self-reported by questionnaire during every consultation session, and it remains possible that some exaggerated reporting occurred.
The findings reported here show that, in clinical practices, not in smoking cessation clinic, a disease management approach with motivational interviewing, associated or not with pharmacotherapy, was effective in helping smokers to quit. Even smokers who are initially unwilling to quit might be engaged in smoking cessation with a significant reduction in daily cigarette smoking. Physicians play a critical role in reducing the burden of tobacco-related health problems by helping their patients who smoke to quit and by motivating their nonsmoking patients to remain nonsmokers. Unfortunately, many physicians report inadequate training in smoking cessation, and many smokers who see physicians do not receive assistance to quit
4. Advances can be made by not only improving the use of existing smoking cessation treatments but also intervention by physicians that increases motivation, self-efficacy and self-esteem.