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DOI: https://doi.org/10.4046/trd.2020.0116    [Accepted]
Published online October 30, 2020.
An overview of genetic information of latency in Mycobacterium tuberculosis
Faezeh Hamidieh, 1, Parissa Farnia, 2  , Jamileh Nowroozi, 1, Poopak Farnia, 2,3, Ali Akbar Velayati, 2
1Microbiology Group, Faculty of Life Science, North Tehran Branch, Islamic Azad University, Tehran, Iran
2Mycobacteriology Research Center (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD) ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
3Department of Biotechnology, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Sciences, Tehran. Iran
Correspondence:  Parissa Farnia,
Email: faezeh_hamidieh@yahoo.com
Received: 18 September 2020   • Revised: 1 October 2020   • Accepted: 30 October 2020
Abstract
Mycobterium tuberculosis has infected more than two billion individuals worldwide, out of whom 5-10% have clinically active diseases and 90-95% remain in the latent form with viable bacteria in the macrophages as their reservoir for extended periods of time. The tubercle bacilli at this stage are usually called dormant, non-viable and/or non-culture able microorganisms. The people with latent bacilli will not have clinical pictures and do not infect another person. About 2-23% of latent status gets reactive in some patients for various reasons such as cancer, HIV infection, diabetes, and/or aging. Many studies have examined the mechanisms involved in the latency state of Mycobacterium and it has been shown that latency modifies the expression of many genes. Therefore, several mechanisms will change in this bacterium. Hence, this study aims to briefly examine the genes involved in the latency state as well as the changes that are caused by MTB. It has also been attempted to evaluate the relationship between the function of these genes.
Key Words: Mycobacterium tuberculosis, Latency, Tuberculosis, Dormancy, Genetics


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