Surfactant replacement therapy in adult respiratory distress syndrome.

Park, Sung Soo; Lee, Jung Hee

doi:1993.40.2.91

Tuberc Respir Dis > Volume 40(2); 1993 > Article

Original Article

Tuberculosis and Respiratory Diseases 1993;40(2):91-97.
DOI: https://doi.org/10.4046/trd.1993.40.2.91 Published online April 1, 1993.

Surfactant replacement therapy in adult respiratory distress syndrome.

Sung Soo Park, Jung Hee Lee

Department of Pulmonary Medicine, College of Medicine, Hanyang University, Seoul, Korea

성인성 호흡곤란 증후군에 있어서 Surfactant 치료

Abstract

Pulmonary surfactant is a lipoprotein complex composed primarily of phospholipid and lung specific apoproteins that reduces surface tension in the alveolus and maintains alveolar stability at low lung volume. Adult respiratory distress syndrome still carries a very high morbidity and mortality. The surfactant system is vital to the maintenance of proper "lung function, any type of surfactant deficiency. whether primary or secondary, will contribute significantly to the development of pulmonary pathophysiology. Various mechanisms in adult respiratory distress syndrome may be responsible for such alterations in the surfactant system. Surfactant replacement is now an estab. li shed treatment for neonatal respiratory distress syndrome , reducing both incidence of complications and mortality. 찌T ith the current knowledge of surfactant physiology and the pathophysiology of the adult respiratory distress syndrome exogenous surfactant treatment or stimulation of endogenous surfactant synthesis and secretion will prove to be beneficial in preventing and treating the adult respiratory distress syndrome. The study of clinical surfactant therapy for adult respiratory distress syndrome is just beginning and this can be viewed as an area with exciting potential. As soon as surfactant preparations become more widely available trials should begin to define the role of surfactant treatment in the adult respiratory distress syndrome as an adjunct to available treatment techniques.

Key Words: Surfactant, Replacemant therapy, ARDS

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