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Tuberc Respir Dis > Volume 40(4); 1993 > Article
Original Article
Tuberculosis and Respiratory Diseases 1993;40(4):395-403.
DOI: https://doi.org/10.4046/trd.1993.40.4.395    Published online August 1, 1993.
Expression of p53 in human primary lung cancers.
Young Kyu Lee1, Sung Soo Park2, Dong Ho Shin2, Dong Hoo Lee2, Jung Hee Lee2, Jung Dal Lee3
1Department of Internal Medicine, Daejeon Eulji Hospital, Daejeon, Korea
2Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea
3Department of Palhology, Hanyang University College of Medicine, Seoul, Korea
Abstract
Background
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Alteration or inactivation of p53 by mutations, or by its interactions with oncogene products of DNA tumor viruses, can lead to cancer. Mutations of the p53 gene occur frequently in human primary lung cancers and the wild.type p 53 allele is often concomitantly deleted These suggest that deprivation of suppressive role of the wild.type p53 may ensure tumor cell growth presumable by the mutant p53 gene.
Methods
In an attempt to investigate this hypothesis, a mutant p53 gene was immunohisto-chemically demonstrated in the formalin.fixed paraffin.embedded tissue sections of lung cancers by using a monoclonal antibody p53 (Ab.3 and clone D07).
Results
The expression of p53 (D07) was found in all four normal lung tissues, four small cell carcinomas, and four non small cell carcinomas in histologic types of lung cancer. In the six normal lung tissues the expressions of p53 (Ab.3) were not found. Contrarily, the expression of p53 (Ab-3) was found in the nuclei of lung cancers among fifteen (46.9%) of thirty.two cases studied. The expression of p53 (Ab-3) was disclosed in three case (37.5%) of eight small cell carcinomas and twelve cases (50 . 0%) of twenty.four non small cell carcinomas in histologic types of lung cancer.
Conclusion
These findings suggest that expression of the mutant p53 is related to the one of events in the pathogenesis of human lung cancer and the role of the other oncogenes might be also related to the development of lung cancers
Key Words: Expression, p53 Gene, Human Primary Lung Cancers
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