| The effect of nasal CPAP in obstructive sleep apnea syndrome. |
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Chi Hong Kim, Soon Seog Kwon, Young Kyoon Kim, Kwan Hyoung Kim, Hwa Sik Moon, Jeong Sup Song, Sung Hak Park |
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Department of Internal Medicine, Catholic University Medical College, Seoul, Korea |
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| Abstract |
Background
Sleep apnea syndrome is a common disorder which is estimated to affect about 1-4% of about male population. And if untreated, sleep apnea can cause significant sequelae, suιh as hypertension, nocturnal cardiac arrhythmia, daytime hypersomnolence, and cognitive impairment.
Various kinds of treatment for obstructive sleep apnea (OSA) have been developed. Among them nasal CPAP, first introduced by SuIlivan et al in 1981 , has received widespread interest and accJa im as a treatment of OSA, and is currently recommended as first-line treatment for OSA. We evaluated the effect of nasal CP AP in OSA and the side effects of nasal CP AP hindering patients from using nasal CPAP.
Methods
We performed sleep studies in 20 OSA patients at 2 consecutive nights; baseline night at first day and CPAP night at second day. We compared apnea index, lowest oxygen concentration during apnea, maximal apnea time, and total apnea duration per total sleep time before and after CPAP. We also evaluated the side effects of CPAP with inquiry to the patients.
Results
1) Apnea index was significantly decreased after CPAP in 17 out of 20 OSA patients (85%) and increased in 3 patients (15%).
2) Average apnea index was significantly decreased after CPAP (34.1± 18. 9/ h→15. 4 ± l0. 3/h, p < 0.01) 3) Total apnea duration per total sleep time was also significantly decreased after CPAP (28. 5 ± 16.0%→ 11. 9 ± 9.3%, p < 0. 05).
4) The lowest oxygen saturation and maximal apnea time were not significantly changed after CPAP .
5) The most frequent side effect of nasal CPAP was mask discomfort (80%), and the next was drying of nasal passages (65%).
Conclusion
Nasal CPAP is an effective treatment for OSA. Further studies should be concentrated on long term foIlow up of nasal CP AP for its therapeutic effects and the study of methods to enhance
patients’ compliance. |
| Key Words:
Obstructive sleep apnea, Nasal CPAP |
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