| A long-term follow up study on pulmanary function after lobectomy and pneumonectomy |
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Yi Hyeong Lee1, Se Kyu Kim1, Joon Chang1, Kyung Young Chung2, Chul Min Ahn1, Sung Kyu Kim1, Won Young Lee1 |
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul,Korea
2Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul,Korea |
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| Abstract |
Background
The functional effects of pulmonary resection are dependent on the preexisting function of resected and remaining tissue as well as on the compensatory potential of the remaining tissue.
Nowadays, large pulmonary resections are usually applied to lung cancer patients often already compromised by chronic lung disease. It is important to evaluate the pulmonary reserve after lung resection preoperatively in the decision of operability and extent of resection. The aim of this study was to evaluate the changes of pulmonary function after pulmonary resection.
Methods
8 lobectomized and 8 pneumonectomized patients were evaluated. The pulmonary function test was performed preoperatively and in immediate postoperative period and thereafter to 5 years at 3 months interval.
Results
1) The pulmonary function 1 week after operation was significantly low compared with predicted values in lobectomy and pneumonectomy groups (p < 0.05), and improved closely to their predicted values 3 months after operation.
2) The FVC was maintained above-predicted value at 6- 24 months and similar to predicted value thereafter in lobectomy group. In pneumonectomy group, the FVC maintained similar to predicted value at 6-36 months and improved above its predicted value thereafter .
3) The FEV1 was maintained simïlar to their predicted values from 6 months to 5 years after operation in both groups.
4) The FEV1 / FVC did not change in the course of time in both groups.
5) The FEF25-75% was maintained similar to predicted value at 6-60 months after operation in lobectomy group, but it decreased under predicted value after 1 year in pneumonectomy group.
6) The MVV was maintained similar to predicted value at 6-24 months and decrease thereafter in lobectomy group. In pneumonectomy group, the MVV was maintained at 6-60 months after operation.
7) The differences in the pulmonary function (FVC, FEV1, FEF25- 75%, MVV) between two groups were seen only at 6 months after operation (p < 0.05).
Conclusion
The pulmonaη function was markedly decreased immediately after operation, improved similar to predicted value at 1- 3 months, highest at 6 months, and maintained similar to the predicted value to 5 years after pulmonary resection. The difference in the pulmonary function between two groups was the most at 6 months after operation. |
| Key Words:
Pulmonary function, Pneumonectomy, Lobectomy, Follow-up |
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