| Relationship between s-phase fraction and survival time in patients with primary squamous lung cancer. |
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Byung Hak Jung1, Jeong Seong Kang1, Keun Chang1, Eun Taik Jeong1, Hun Taeg Chung2, Hyung Bae Moon3 |
1Department of Internal Medicine, Wonkwang University College of Medicine, Iri, Korea.
2Department of Microbiology, Wonkwang University College of Medicine, Iri, Korea.
3Department of Pathology, Wonkwang University College of Medicine, Iri, Korea. |
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| Abstract |
Background
DNA content analysis of human solid tumor is now widely performed by flow cytometric study. One of the most interesting and potentially important observation in this field is that proliferative activity (S.Phase fraction of cell cycle) may profoundly affect prognosis.
Methods
S.Phase fraction (SPF) have been measured by flow cytometric method using tumor cells isolated from paraffin-embedded tissue. To evaluate the prognostic significance, SPF of squamous lung cancer cell was assessed in 21 patients who died without any specific treatment .
Results
1) Mean survival time of squamous lung cancer patients was 225( ± 162) days. Survival time were shortened, when TNM stage and PS scale were advanced. 2) Mean value of SPF of sQuamous lung cancer patients was 23. 4( ± 11.3)%. SPF had nothing to do with advance of TNM stage and PS scale. 3) Mean survival time of high SPF group (more than 20% of cell proliferation cycle) and low SPF group were 153( ± 99) days and 342( ± 180 days (p < 0.01). In each identical TNM stage and PS scale, there were also statistic significant differences in mean survival time between high and low SPF group.
Conclusion
On multivariate analysis including TNM stage and performance status, SPF was the significant and independent prognostic factor in the primary squamous lung cancer patients group. |
| Key Words:
Lung cancer, S-phase fraction, Survival time |
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