Change of Soluble RANTES Levels in Serum from Pateints with Atopic Bronchial Asthma.

Rhee, Yang Keun; Kim, Jae Hean; Lee, Yong Chul

doi:1996.43.2.182

Tuberc Respir Dis > Volume 43(2); 1996 > Article

Original Article

Tuberculosis and Respiratory Diseases 1996;43(2):182-189.
DOI: https://doi.org/10.4046/trd.1996.43.2.182 Published online April 1, 1996.

Change of Soluble RANTES Levels in Serum from Pateints with Atopic Bronchial Asthma.

Yang Keun Rhee, Jae Hean Kim, Yong Chul Lee

Department of Internal Medicine, Chonbuk National Unversity Medical School, Chonju, Korea.

Abstract

BACKGROUND
RANTES is associated with chemotaxis and activation of eosinophils. RANTES is up-regulated in allegic inflammation and play a critical role in the pathogenesis of allegic inflammation. Recently, circulating form of RANTES have been identified in the peripheral blood. METHOD: In the present study, we measured soluble RANTES levels in 17 patients with atopic brochial asthma (8 patients: early response to allegen challenge, 8 patients: early and late response to allergen challenge) on 30mins, 2hrs and 8 hrs after allergen challenge with house dust mite, prechallenge period. RESULT: RANTES levels in sera from patients with bronchial astma in prechallenge conditions were higher than in normal control subjects. But, RANTES levels in sera from patients with bronchial asthma in 30mins, 2hrs and 8hrs after challenge were no significantly higher than prechallenge conditions. CONCLUSION: These results suggest that RANTES plays a role in the pathogenesis of patients with atopic bronchial asthma and may be related to persistence of subclinical allergic inflammation.

Key Words: RANTES, Bronchial asthma