Prognostic Value of Vascular Endothelial Growth Factor(VEGF) in Resected Non-Small Cell Lung Cancer.

Ko, Hyeck Jae; Park, Jeong Hyun; Shim, Hyeok; Yang, Sei Hoon; Jeong, Eun Taik

doi:2001.50.6.676

Tuberc Respir Dis > Volume 50(6); 2001 > Article

Original Article

Tuberculosis and Respiratory Diseases 2001;50(6):676-685.
DOI: https://doi.org/10.4046/trd.2001.50.6.676 Published online June 1, 2001.

Prognostic Value of Vascular Endothelial Growth Factor(VEGF) in Resected Non-Small Cell Lung Cancer.

Hyeck Jae Ko, Jeong Hyun Park, Hyeok Shim, Sei Hoon Yang, Eun Taik Jeong

Abstract

BACKGROUND
Angiogenesis is an essential component of tumor growth and metastasis, and the vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. Several solid tumors produce substantial amounts of VEGF, which stimulates proliferation and the migration of ednothelial cells, therby inducing neovasculization by a paracrine mechanism. To evaluate the prognostic roles of angiogenesis and VEGF expression in patients with non-small cell lung cancer, the relationship between VEGF expression in tumor tissues, the clinicopathologic features and the overall survival rate were analysed. METHODS: Sixty-nine resected primary non-small cell lung cancer specimens were evaluated. The pareffinembedded tumor tissues were stained by anti-VEGF polyclonal antibodies using an immunohistochemical method to assess VEGF expression. RESULTS: In Forty-one patients (59%), the VEGF antigen was expressed weakly in their tumor tissue, whereas in twenty-eight patients (41%) the VEGF antigen was expressed strongly. The median survival time of the weak VEGF expression group was 24 months, and that of the strong VEGF expression group was 19 months. The three year-survival rates were 35%, 33%, respectively. The survival difference between both groups was not statistically significnat. CONCLUSION: Although results were not statistically significant, the strong expression group tended to poorer prognosis than weak expression group.

Key Words: Non-small cell lung cancer, angiogenesis, VEGF, Survival tim