A Case of Primary Pulmonary Sarcoma with Morphologic Features of Malignant Fibrous Histiocytoma.

Lee, Youn Jeong; Hur, Won Haing; Lo, Dae Keun; Kim, Seung Joon; Lee, Sook Young; Kim, Young Kyoon; Moon, Hwa Sik; Song, Jeong Sup; Park, Sung Hak; Park, Gyeong Sin; Lee, Kyo Young

doi:2002.52.2.186

Tuberc Respir Dis > Volume 52(2); 2002 > Article

Case Report

Tuberculosis and Respiratory Diseases 2002;52(2):186-191.
DOI: https://doi.org/10.4046/trd.2002.52.2.186 Published online February 1, 2002.

A Case of Primary Pulmonary Sarcoma with Morphologic Features of Malignant Fibrous Histiocytoma.

Youn Jeong Lee, Won Haing Hur, Dae Keun Lo, Seung Joon Kim, Sook Young Lee, Young Kyoon Kim, Hwa Sik Moon, Jeong Sup Song, Sung Hak Park, Gyeong Sin Park, Kyo Young Lee

¹Department of Internal Medicine, Catholic University of Korea, School of Medicine, Seoul, Korea. cmcpsh@cmc.cuk.ac.kr
²Department of Clinical pathology, Catholic University of Korea, School of Medicine, Seoul, Korea.

Abstract

A malignant fibrous histiocytoma is a malignant soft tissue neoplasm that occurs frequently in the metaphyseal ends of the long bones of adults. The lung is a common site for metastasis but it is a rare site for a primary malignant fibrous histiocytoma. Here we report a case of a primary malignant fibrous histiocytoma of the lung. The patient was a 53-year-old man who presented with a moderate amount of a left pleural effusion and an ill-defined mass in the left lower lobe on a chest radiograph and a local invasion to the left 10th and 11th rib on chest CT. Under the strong suspicion of lung cancer with a pleural invasion, a serial diagnostic thoracentesis was performed. The cytologic examination of the pleural effusion revealed no malignant cells. Consequently, a thoracoscopic pleural biopsy was performed. The histological examination revealed slender spindle cells and scattered epitheloid cells arranged in a vague storiform or a whirling pattern. Immunohistochemically, the tumor cells tested positive for vimentin and negative for cytokeratin, desmin, CD34 and PAS. These features were consistent with a malignant fibrous histiocytoma. This case is an unusual addition to the small number of published reports on a primary malignant fibrous histiocytoma of the lung.

Key Words: Malignant fibrous histiocytoma, Lung sarcoma, Vimentin