A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia.

Hahn, Chang Hoon; Moon, Jin Wook; Chang, Jae Hyun; Choi, Byoung Wook; Shin, Dong Whan; Kim, Se Kyu; Chang, Joon; Kim, Sung Kyu; Kim, Young Sam

doi:2003.55.3.311

Tuberc Respir Dis > Volume 55(3); 2003 > Article

Case Report

Tuberculosis and Respiratory Diseases 2003;55(3):311-316.
DOI: https://doi.org/10.4046/trd.2003.55.3.311 Published online September 1, 2003.

A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia.

Chang Hoon Hahn, Jin Wook Moon, Jae Hyun Chang, Byoung Wook Choi, Dong Whan Shin, Se Kyu Kim, Joon Chang, Sung Kyu Kim, Young Sam Kim

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. ysamkim@yumc.yonsei.ac.kr
²Department of Institute of Chest Diseases, Yonsei University College of Medicine, Seoul, Korea.
³Department of Diagnostic Radiology, Yonsei University College of Medicine, Seoul, Korea.
⁴Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Abstract

A 34-year-old man was admitted to our hospital due to fever and cough. He received the combination anti-cancer chemotherapy for testicular tumor, including bleomycin. The chest X-ray showed consolidation and ground glass opacity on the right upper lobe and subpleural areas of other lobes. This condition was initially misdiagnosed as a pneumonia, but consolidation did not disappear after antibiotics treatment. We performed transbronchial lung biopsy and bleomycin induced pulmonary toxicity was confirmed. The bleomycin induced lung injury is the most common chemotherapeutically induced pulmonary disease. Bleomycin induced Bronchiolitis Obliterans Organizing Pneumonia(BOOP) is less common than interstitial pneumonitis and respond well to corticosteroid treatment.

Key Words: Bleomycin, Pulmonary toxicity, BOOP