Tuberc Respir Dis Search

CLOSE


Tuberc Respir Dis > Volume 57(2); 2004 > Article
Tuberculosis and Respiratory Diseases 2004;57(2):180-182.
DOI: https://doi.org/10.4046/trd.2004.57.2.180    Published online August 1, 2004.
A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis.
Ho Seok Jeon, Min Soo Han, Ju Eui Ahn, Yang Deok Lee, Yongseon Cho
Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea. hms43@freechal.com
Abstract
A Case of Pellagra Induced by Isoniazid during Treatment of Pulmonary Tuberculosis Pellagra is a disease caused by a deficiency of nicotinic acid or niacin. It is mostly found among people eating corn-based diets in parts of China, Africa and India. It is also induced by drugs, such as isoniazid or 5-fluorouracil. Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients. Pellagra should be suspected whenever tuberculous patients under the treatment with isoniazid develop mental, neurological or gastrointestinal symptoms, even in the absence of typical skin changes. Herein, our experienced of a case of pellagra induced by isoniazid during treatment of pulmonary tuberculosis is reported. The patient was referred due to a skin rash and drowsy mental status. Her skin lesion developed during treatment for pulmonary tuberculosis. Her symptoms were improved after discontinuation of antituberculous agents and on the administration of nicotinamide.
Key Words: Pellagra, Isoniazid, Pulmonary tuberculosis


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
FOR CONTRIBUTORS
Editorial Office
101-605, 58, Banpo-daero, Seocho-gu (Seocho-dong, Seocho Art-Xi), Seoul 06652, Korea
Tel: +82-2-575-3825, +82-2-576-5347    Fax: +82-2-572-6683    E-mail: katrdsubmit@lungkorea.org                

Copyright © 2021 by The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Developed in M2PI

Close layer
prev next